Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly population

Mansi Dalal, Richard David Semba, Kai Sun, Candace Crasto, Ravi Varadhan, Stefania Bandinelli, Jeffrey C. Fink, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background/Aims: The relationship of circulating endogenous secretory receptor for advanced glycation end products (esRAGE) and chronic kidney disease (CKD) has not been well characterized. The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults. Methods: The relationship between plasma esRAGE and CKD (more than stage 3 of the National Kidney Foundation classification; estimated glomerular filtration rate 2) and CKD over 6 years of follow-up was examined in a cross-sectional and prospective study design in 1,016 men and women, ≥65 years, in the InCHIANTI study, a population-based cohort study of aging in Tuscany, Italy. Results: At enrollment, 158 (15.5%) had CKD. Mean (SD) plasma esRAGE was 0.45 (0.24) ng/ml. Plasma esRAGE (ng/ml) was associated with CKD (odds ratio per 1 SD = 1.30; 95% CI 1.1-1.6; p <0.005) in a multivariable logistic regression model, adjusting for potential confounders. Plasma esRAGE was an independent predictor of incident CKD over 6 years of follow-up (hazard ratio per 1 SD = 1.37; 95% CI 1.1-1.7; p <0.008) in a multivariable Cox proportional hazards model, adjusting for potential confounders. Conclusions: Elevated plasma esRAGE is independently associated with CKD and is an independent predictor of incident CKD in older community-dwelling adults.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalAmerican Journal of Nephrology
Volume33
Issue number4
DOIs
StatePublished - Apr 2011

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Chronic Renal Insufficiency
Population
Logistic Models
Advanced Glycosylation End Product-Specific Receptor
Independent Living
Glomerular Filtration Rate
Proportional Hazards Models
Italy
Cohort Studies
Cross-Sectional Studies
Odds Ratio
Prospective Studies
Kidney

Keywords

  • Advanced glycation end products
  • Aging
  • Chronic kidney disease
  • Endogenous secretory receptor for advanced glycation end products

ASJC Scopus subject areas

  • Nephrology

Cite this

Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly population. / Dalal, Mansi; Semba, Richard David; Sun, Kai; Crasto, Candace; Varadhan, Ravi; Bandinelli, Stefania; Fink, Jeffrey C.; Guralnik, Jack M.; Ferrucci, Luigi.

In: American Journal of Nephrology, Vol. 33, No. 4, 04.2011, p. 313-318.

Research output: Contribution to journalArticle

Dalal, Mansi ; Semba, Richard David ; Sun, Kai ; Crasto, Candace ; Varadhan, Ravi ; Bandinelli, Stefania ; Fink, Jeffrey C. ; Guralnik, Jack M. ; Ferrucci, Luigi. / Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly population. In: American Journal of Nephrology. 2011 ; Vol. 33, No. 4. pp. 313-318.
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abstract = "Background/Aims: The relationship of circulating endogenous secretory receptor for advanced glycation end products (esRAGE) and chronic kidney disease (CKD) has not been well characterized. The aim of the study was to determine whether plasma esRAGE is associated with CKD and is predictive of developing CKD in older adults. Methods: The relationship between plasma esRAGE and CKD (more than stage 3 of the National Kidney Foundation classification; estimated glomerular filtration rate 2) and CKD over 6 years of follow-up was examined in a cross-sectional and prospective study design in 1,016 men and women, ≥65 years, in the InCHIANTI study, a population-based cohort study of aging in Tuscany, Italy. Results: At enrollment, 158 (15.5{\%}) had CKD. Mean (SD) plasma esRAGE was 0.45 (0.24) ng/ml. Plasma esRAGE (ng/ml) was associated with CKD (odds ratio per 1 SD = 1.30; 95{\%} CI 1.1-1.6; p <0.005) in a multivariable logistic regression model, adjusting for potential confounders. Plasma esRAGE was an independent predictor of incident CKD over 6 years of follow-up (hazard ratio per 1 SD = 1.37; 95{\%} CI 1.1-1.7; p <0.008) in a multivariable Cox proportional hazards model, adjusting for potential confounders. Conclusions: Elevated plasma esRAGE is independently associated with CKD and is an independent predictor of incident CKD in older community-dwelling adults.",
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AU - Varadhan, Ravi

AU - Bandinelli, Stefania

AU - Fink, Jeffrey C.

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AU - Ferrucci, Luigi

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