Endogenous opioid activity and β-endorphin immunoreactivity in CSF of psychiatric patients and normal volunteers

D. Naber, D. Pickar, R. M. Post, D. P. Van Kammen, R. N. Waters, J. C. Ballenger, F. K. Goodwin, W. E. Bunney

Research output: Contribution to journalArticle

Abstract

The authors measured total opioid activity by radioreceptor assay in the CSF of 41 normal subjects and 89 unmedicated psychiatric patients, including schizophrenic, schizoaffective, depressed, and manic diagnostic groups. Schizophrenic men had significantly lower levels of opioid activity than the normal men, although these levels did not significantly differ from levels of other male patients. The authors observed higher opioid activity during mania than during depression in paired samples from 4 manic-depressive patients. β-Endorphin immunoreactivity in a subsample of the same subjects was no different in the patient group than in the normal group, suggesting that the differences in CSF opioid activity between schizophrenic men and normal patients may be related to opioids other than β-endorphin.

Original languageEnglish (US)
Pages (from-to)1457-1462
Number of pages6
JournalAmerican Journal of Psychiatry
Volume138
Issue number11
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Naber, D., Pickar, D., Post, R. M., Van Kammen, D. P., Waters, R. N., Ballenger, J. C., Goodwin, F. K., & Bunney, W. E. (1981). Endogenous opioid activity and β-endorphin immunoreactivity in CSF of psychiatric patients and normal volunteers. American Journal of Psychiatry, 138(11), 1457-1462.