TY - JOUR
T1 - Endogenous opiates in the mediation of early meal-induced jejunal absorption of water and electrolytes
AU - Augusto Bastidas., J.
AU - Yeo, C. J.
AU - Schmieg, R. E.
AU - Zinner, M. J.
PY - 1989
Y1 - 1989
N2 - The purpose of this study was to investigate the role of endogenous opiates in mediating meal-stimulated jejunal absorption. Jejunal Thiry-Vella loops, 25 cm long, were studied in awake conditioned dogs, using luminal perfusion with carbon- 14 polyethylene glycol. Fluxes of water, sodium, and chloride were calculated every 15 minutes over a 1-hour basal period, followed by a 3-hour experimental period. The animals were divided into four groups: control, naloxone, meal, and meal plus naloxone. In the control and naloxone groups, the fluxes did not change over the 4-hour observation period. Meal alone immediately stimulated the absorption of water and electrolytes in the Thiry-Vella loop (p <0.05). The addition of naloxone infusion to the meal stimulus resulted in significantly reduced absorption during the first hour after the meal (p <0.05). We concluded that endogenous opiates play a role in meal-stimulated jejunal absorption.
AB - The purpose of this study was to investigate the role of endogenous opiates in mediating meal-stimulated jejunal absorption. Jejunal Thiry-Vella loops, 25 cm long, were studied in awake conditioned dogs, using luminal perfusion with carbon- 14 polyethylene glycol. Fluxes of water, sodium, and chloride were calculated every 15 minutes over a 1-hour basal period, followed by a 3-hour experimental period. The animals were divided into four groups: control, naloxone, meal, and meal plus naloxone. In the control and naloxone groups, the fluxes did not change over the 4-hour observation period. Meal alone immediately stimulated the absorption of water and electrolytes in the Thiry-Vella loop (p <0.05). The addition of naloxone infusion to the meal stimulus resulted in significantly reduced absorption during the first hour after the meal (p <0.05). We concluded that endogenous opiates play a role in meal-stimulated jejunal absorption.
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M3 - Article
C2 - 2910124
SN - 0002-9610
VL - 157
SP - 27
EP - 32
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 1
ER -