Endogenous neurosteroid synthesis modulates seizure frequency

Courtney Lawrence, Brandon Scott Martin, Chengsan Sun, John Williamson, Jaideep Kapur

Research output: Contribution to journalArticlepeer-review

Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

Original languageEnglish (US)
Pages (from-to)689-693
Number of pages5
JournalAnnals of neurology
Volume67
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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