Endogenous GABAergic modulators in the pathogenesis of hepatic encephalopathy

Jeffrey D. Rothstein, Marjut Olasmaa

Research output: Contribution to journalArticlepeer-review

Abstract

Theories on the neurochemical etiology for hepatic encephalopathy have recently focussed on activation of inhibitory neurotransmitter GABA systems. Modulators of the GABAA receptor complex, including diazepam binding inhibitor, are significantly and selectively altered in hepatic encephalopathy. In animals and humans, benzodiazepine receptor antagonists rapidly ameliorate this syndrome suggesting the possible existence of an endogenous benzodiazepine-like substance. Endogenous GABAergic modulators may contribute to the neurochemical pathogenesis of hepatic encephalopathy.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalNeurochemical Research
Volume15
Issue number2
DOIs
StatePublished - Feb 1 1990

Keywords

  • DBI
  • GABA
  • Hepatic encephalopathy
  • benzodiazepine
  • cerebrospinal fluid

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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