Endogenous endothelial cell signaling systems maintain vascular stability

Nyall London, Kevin J. Whitehead, Dean Y. Li

Research output: Contribution to journalArticle

Abstract

The function of the endothelium is to provide a network to allow delivery of oxygen and nutrients to tissues throughout the body. This network comprises adjacent endothelial cells that utilize adherens junction proteins such as vascular endothelial cadherin (VE-cadherin) to maintain the appropriate level of vascular permeability. The disruption of VE-cadherin interactions during pathologic settings can lead to excessive vascular leak with adverse effects. Endogenous cell signaling systems have been defined, which help to maintain the proper level of vascular stability. Perhaps the best described system is Angiopoietin-1 (Ang-1). Ang-1 acting through its receptor Tie2 generates a well-described set of signaling events ultimately leading to enhanced vascular stability. In this review, we will focus on what is known about additional endogenous cell signaling systems that stabilize the vasculature, and using Ang-1/Tie2 as a model, we will address where our understanding of these additional systems is lacking.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalAngiogenesis
Volume12
Issue number2
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Angiopoietin-1
Cell signaling
Endothelial cells
Blood Vessels
Endothelial Cells
TIE-2 Receptor
Adherens Junctions
Capillary Permeability
Nutrients
Endothelium
Tissue
Oxygen
Food
Proteins
cadherin 5

Keywords

  • CCM
  • Permeability
  • Robo4
  • Vascular stability
  • VE-cadherin

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cancer Research

Cite this

Endogenous endothelial cell signaling systems maintain vascular stability. / London, Nyall; Whitehead, Kevin J.; Li, Dean Y.

In: Angiogenesis, Vol. 12, No. 2, 01.06.2009, p. 149-158.

Research output: Contribution to journalArticle

London, Nyall ; Whitehead, Kevin J. ; Li, Dean Y. / Endogenous endothelial cell signaling systems maintain vascular stability. In: Angiogenesis. 2009 ; Vol. 12, No. 2. pp. 149-158.
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