Abstract
The function of the endothelium is to provide a network to allow delivery of oxygen and nutrients to tissues throughout the body. This network comprises adjacent endothelial cells that utilize adherens junction proteins such as vascular endothelial cadherin (VE-cadherin) to maintain the appropriate level of vascular permeability. The disruption of VE-cadherin interactions during pathologic settings can lead to excessive vascular leak with adverse effects. Endogenous cell signaling systems have been defined, which help to maintain the proper level of vascular stability. Perhaps the best described system is Angiopoietin-1 (Ang-1). Ang-1 acting through its receptor Tie2 generates a well-described set of signaling events ultimately leading to enhanced vascular stability. In this review, we will focus on what is known about additional endogenous cell signaling systems that stabilize the vasculature, and using Ang-1/Tie2 as a model, we will address where our understanding of these additional systems is lacking.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 149-158 |
| Number of pages | 10 |
| Journal | Angiogenesis |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2009 |
| Externally published | Yes |
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Keywords
- CCM
- Permeability
- Robo4
- Vascular stability
- VE-cadherin
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Cancer Research
Cite this
Endogenous endothelial cell signaling systems maintain vascular stability. / London, Nyall; Whitehead, Kevin J.; Li, Dean Y.
In: Angiogenesis, Vol. 12, No. 2, 01.06.2009, p. 149-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous endothelial cell signaling systems maintain vascular stability
AU - London, Nyall
AU - Whitehead, Kevin J.
AU - Li, Dean Y.
PY - 2009/6/1
Y1 - 2009/6/1
N2 - The function of the endothelium is to provide a network to allow delivery of oxygen and nutrients to tissues throughout the body. This network comprises adjacent endothelial cells that utilize adherens junction proteins such as vascular endothelial cadherin (VE-cadherin) to maintain the appropriate level of vascular permeability. The disruption of VE-cadherin interactions during pathologic settings can lead to excessive vascular leak with adverse effects. Endogenous cell signaling systems have been defined, which help to maintain the proper level of vascular stability. Perhaps the best described system is Angiopoietin-1 (Ang-1). Ang-1 acting through its receptor Tie2 generates a well-described set of signaling events ultimately leading to enhanced vascular stability. In this review, we will focus on what is known about additional endogenous cell signaling systems that stabilize the vasculature, and using Ang-1/Tie2 as a model, we will address where our understanding of these additional systems is lacking.
AB - The function of the endothelium is to provide a network to allow delivery of oxygen and nutrients to tissues throughout the body. This network comprises adjacent endothelial cells that utilize adherens junction proteins such as vascular endothelial cadherin (VE-cadherin) to maintain the appropriate level of vascular permeability. The disruption of VE-cadherin interactions during pathologic settings can lead to excessive vascular leak with adverse effects. Endogenous cell signaling systems have been defined, which help to maintain the proper level of vascular stability. Perhaps the best described system is Angiopoietin-1 (Ang-1). Ang-1 acting through its receptor Tie2 generates a well-described set of signaling events ultimately leading to enhanced vascular stability. In this review, we will focus on what is known about additional endogenous cell signaling systems that stabilize the vasculature, and using Ang-1/Tie2 as a model, we will address where our understanding of these additional systems is lacking.
KW - CCM
KW - Permeability
KW - Robo4
KW - Vascular stability
KW - VE-cadherin
UR - http://www.scopus.com/inward/record.url?scp=67650764015&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650764015&partnerID=8YFLogxK
U2 - 10.1007/s10456-009-9130-z
DO - 10.1007/s10456-009-9130-z
M3 - Article
C2 - 19172407
AN - SCOPUS:67650764015
VL - 12
SP - 149
EP - 158
JO - Angiogenesis
JF - Angiogenesis
SN - 0969-6970
IS - 2
ER -