Endogenous CCK in the control of gastric emptying of glucose and maltose

Timothy H. Moran; Douglas G. Field; Susan Knipp; Timothy S. Carrigan; Gary J. Schwartz

doi:10.1016/S0196-9781(97)00062-4

Endogenous CCK in the control of gastric emptying of glucose and maltose

Timothy H. Moran, Douglas G. Field, Susan Knipp, Timothy S. Carrigan, Gary J. Schwartz

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

Original language	English (US)
Pages (from-to)	547-550
Number of pages	4
Journal	Peptides
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/S0196-9781(97)00062-4
State	Published - 1997

Keywords

CCK(A)
Devazepide
Gastric emptying
Rhesus monkeys

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/S0196-9781(97)00062-4

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title = "Endogenous CCK in the control of gastric emptying of glucose and maltose",

abstract = "A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.",

keywords = "CCK(A), Devazepide, Gastric emptying, Rhesus monkeys",

author = "Moran, {Timothy H.} and Field, {Douglas G.} and Susan Knipp and Carrigan, {Timothy S.} and Schwartz, {Gary J.}",

note = "Funding Information: We appreciate the generous gift of devazepide from Dr. R.M. Freidinger of Merck Research Laboratories. This work was supported by NIH grants DK19302 and MH15330. ",

year = "1997",

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T1 - Endogenous CCK in the control of gastric emptying of glucose and maltose

AU - Moran, Timothy H.

AU - Field, Douglas G.

AU - Knipp, Susan

AU - Carrigan, Timothy S.

AU - Schwartz, Gary J.

N1 - Funding Information: We appreciate the generous gift of devazepide from Dr. R.M. Freidinger of Merck Research Laboratories. This work was supported by NIH grants DK19302 and MH15330.

PY - 1997

Y1 - 1997

N2 - A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

AB - A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 μg/kg) of the CCK(A) receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μg/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.

KW - CCK(A)

KW - Devazepide

KW - Gastric emptying

KW - Rhesus monkeys

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SN - 0196-9781

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ER -

Endogenous CCK in the control of gastric emptying of glucose and maltose

Abstract

Keywords

ASJC Scopus subject areas

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