Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats

Vladimir A. Kashkin, Edwin E. Zvartau, Olga V. Fedorova, Yakov Y. Bagrov, Edward G. Lakatta, Alexei Y. Bagrov

Research output: Contribution to journalArticle

Abstract

An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague-Dawley rats, forced ethanol intake (20% v/v, 2.8 ± 0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalEuropean Neuropsychopharmacology
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • Ethanol
  • Hypertension
  • Marinobufagenin
  • Na/K-ATPase
  • NaCl sensitivity
  • Rat
  • Withdrawal

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats'. Together they form a unique fingerprint.

  • Cite this