Abstract
Female hyperandrogenism is often associated with hyper-insulinaemia and insulin resistance. We evaluated the hormone responses in an oral glucose tolerance test to investigate the interactions of gonadotrophins, insulin, C-peptide and androgens in women with polycystic ovarian disease (PCOD). In 28 patients with ultrasonographically diagnosed PCOD, hyperinsulinaemia and insulin resistance were mainly associated with obesity. Both basal and cumulative sum of insulin to C-peptide ratios were high in obese subjects, suggesting decreasing hepatic removal of insulin caused by obesity. Nevertheless, in some lean PCOD women, despite normal fasting insulin concentrations, insulin hyper-secretion existed. The mean concentration of testosterone decreased significantly during the oral glucose tolerance test both in PCOD and control women, and of androstenedione in the PCOD patients only. However, an increase in androgen responses was found in a subgroup of PCOD patients, who had both elevated luteinizing hormone (LH) concentrations and hyperinsulinaemic response to oral glucose. In the remaining PCOD patients an inverse correlation between LH and insulin was found. The patients with hyperinsulinaemia together with LH hypersecretion may represent a subgroup of PCOD with deranged regulation of androgen secretion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1179-1183 |
| Number of pages | 5 |
| Journal | Human Reproduction |
| Volume | 8 |
| Issue number | 8 |
| State | Published - Aug 1993 |
| Externally published | Yes |
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Keywords
- Androgens
- C-peptide
- Gonadotrophins
- Insulin
- Polycystic ovarian disease
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Reproductive Medicine
- Obstetrics and Gynecology
- Rehabilitation
- Developmental Biology
- Physiology
Cite this
Endocrinology : Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic ovarian disease. / Anttila, L.; Koskinen, P.; Jaatinen, T. A.; Erkkola, R.; Irjala, K.; Altman, Kristiina R.
In: Human Reproduction, Vol. 8, No. 8, 08.1993, p. 1179-1183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endocrinology
T2 - Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic ovarian disease
AU - Anttila, L.
AU - Koskinen, P.
AU - Jaatinen, T. A.
AU - Erkkola, R.
AU - Irjala, K.
AU - Altman, Kristiina R
PY - 1993/8
Y1 - 1993/8
N2 - Female hyperandrogenism is often associated with hyper-insulinaemia and insulin resistance. We evaluated the hormone responses in an oral glucose tolerance test to investigate the interactions of gonadotrophins, insulin, C-peptide and androgens in women with polycystic ovarian disease (PCOD). In 28 patients with ultrasonographically diagnosed PCOD, hyperinsulinaemia and insulin resistance were mainly associated with obesity. Both basal and cumulative sum of insulin to C-peptide ratios were high in obese subjects, suggesting decreasing hepatic removal of insulin caused by obesity. Nevertheless, in some lean PCOD women, despite normal fasting insulin concentrations, insulin hyper-secretion existed. The mean concentration of testosterone decreased significantly during the oral glucose tolerance test both in PCOD and control women, and of androstenedione in the PCOD patients only. However, an increase in androgen responses was found in a subgroup of PCOD patients, who had both elevated luteinizing hormone (LH) concentrations and hyperinsulinaemic response to oral glucose. In the remaining PCOD patients an inverse correlation between LH and insulin was found. The patients with hyperinsulinaemia together with LH hypersecretion may represent a subgroup of PCOD with deranged regulation of androgen secretion.
AB - Female hyperandrogenism is often associated with hyper-insulinaemia and insulin resistance. We evaluated the hormone responses in an oral glucose tolerance test to investigate the interactions of gonadotrophins, insulin, C-peptide and androgens in women with polycystic ovarian disease (PCOD). In 28 patients with ultrasonographically diagnosed PCOD, hyperinsulinaemia and insulin resistance were mainly associated with obesity. Both basal and cumulative sum of insulin to C-peptide ratios were high in obese subjects, suggesting decreasing hepatic removal of insulin caused by obesity. Nevertheless, in some lean PCOD women, despite normal fasting insulin concentrations, insulin hyper-secretion existed. The mean concentration of testosterone decreased significantly during the oral glucose tolerance test both in PCOD and control women, and of androstenedione in the PCOD patients only. However, an increase in androgen responses was found in a subgroup of PCOD patients, who had both elevated luteinizing hormone (LH) concentrations and hyperinsulinaemic response to oral glucose. In the remaining PCOD patients an inverse correlation between LH and insulin was found. The patients with hyperinsulinaemia together with LH hypersecretion may represent a subgroup of PCOD with deranged regulation of androgen secretion.
KW - Androgens
KW - C-peptide
KW - Gonadotrophins
KW - Insulin
KW - Polycystic ovarian disease
UR - http://www.scopus.com/inward/record.url?scp=0027201962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027201962&partnerID=8YFLogxK
M3 - Article
C2 - 8408513
AN - SCOPUS:0027201962
VL - 8
SP - 1179
EP - 1183
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 8
ER -