Endocrinology: Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic ovarian disease

L. Anttila, P. Koskinen, T. A. Jaatinen, R. Erkkola, K. Irjala, Kristiina R Altman

Research output: Contribution to journalArticle

Abstract

Female hyperandrogenism is often associated with hyper-insulinaemia and insulin resistance. We evaluated the hormone responses in an oral glucose tolerance test to investigate the interactions of gonadotrophins, insulin, C-peptide and androgens in women with polycystic ovarian disease (PCOD). In 28 patients with ultrasonographically diagnosed PCOD, hyperinsulinaemia and insulin resistance were mainly associated with obesity. Both basal and cumulative sum of insulin to C-peptide ratios were high in obese subjects, suggesting decreasing hepatic removal of insulin caused by obesity. Nevertheless, in some lean PCOD women, despite normal fasting insulin concentrations, insulin hyper-secretion existed. The mean concentration of testosterone decreased significantly during the oral glucose tolerance test both in PCOD and control women, and of androstenedione in the PCOD patients only. However, an increase in androgen responses was found in a subgroup of PCOD patients, who had both elevated luteinizing hormone (LH) concentrations and hyperinsulinaemic response to oral glucose. In the remaining PCOD patients an inverse correlation between LH and insulin was found. The patients with hyperinsulinaemia together with LH hypersecretion may represent a subgroup of PCOD with deranged regulation of androgen secretion.

Original languageEnglish (US)
Pages (from-to)1179-1183
Number of pages5
JournalHuman Reproduction
Volume8
Issue number8
StatePublished - Aug 1993
Externally publishedYes

Fingerprint

Endocrinology
Ovarian Diseases
Insulin
Secretion
Hormones
Glucose Tolerance Test
Luteinizing Hormone
Glucose
Androgens
Tolerance
Obesity
C-Peptide
Hyperinsulinism
Peptides
Insulin Resistance
Subgroup
Hyperandrogenism
Gonadotropins
Disease Resistance
Cumulative Sum

Keywords

  • Androgens
  • C-peptide
  • Gonadotrophins
  • Insulin
  • Polycystic ovarian disease

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Rehabilitation
  • Developmental Biology
  • Physiology

Cite this

Endocrinology : Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic ovarian disease. / Anttila, L.; Koskinen, P.; Jaatinen, T. A.; Erkkola, R.; Irjala, K.; Altman, Kristiina R.

In: Human Reproduction, Vol. 8, No. 8, 08.1993, p. 1179-1183.

Research output: Contribution to journalArticle

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