Endocrine tests in phenotypic children with bilateral impalpable testes can reliably predict "congenital" anorchism

Selwyn B. Levitt, Edna H. Sobel, Stanley J. Kogan, Robin H. Mortimer, Keith M. Schneider, Rainer M.E. Engel, Jerrold M. Becker

Research output: Contribution to journalArticle

Abstract

Congenital anorchism is a rare condition. Bilateral impalpable undescended testes are relatively common by comparison. Surgical exploration has been regarded as the final arbiter between anorchism and bilateral cryptorchism. Exploration has not proved completely reliable in making this differentiation. Endocrine studies, particularly the human chorionic gonadotropin (HCG) stimulation test together with measurements of basal plasma gonadotropins, can reliably exclude "functioning" testicular tissue. Eleven fully evaluated and operated cases support this contention. In the specific clinical setting of a normal phenotypic male child with a 46XY karyotype and no müllerian structures palpable on rectal examination, nonfunctioning testes on endocrine testing means congenital anorchism and surgical confirmation is unnecessary. In contradistinction, a positive HCG test would appear to mandate thorough and extensive surgical exploration.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalUrology
Volume11
Issue number1
DOIs
StatePublished - Jan 1978

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Endocrine tests in phenotypic children with bilateral impalpable testes can reliably predict "congenital" anorchism'. Together they form a unique fingerprint.

  • Cite this

    Levitt, S. B., Sobel, E. H., Kogan, S. J., Mortimer, R. H., Schneider, K. M., Engel, R. M. E., & Becker, J. M. (1978). Endocrine tests in phenotypic children with bilateral impalpable testes can reliably predict "congenital" anorchism. Urology, 11(1), 11-17. https://doi.org/10.1016/0090-4295(78)90192-9