Endocrine sequelae of childhood craniopharyngioma

B. Bin-Abbas, H. Mawlawi, N. Sakati, Y. Khafaja, M. A. Chaudhary, A. Al-Ashwal

Research output: Contribution to journalArticle

Abstract

The endocrine sequelae of 62 children with craniopharyngioma were studied retrospectively. These patients were followed for a median duration of 3 years (range 1 to 10 years). Eighteen patients had a long-term follow-up for more than 5 years (range 5 to 10 years). Complete surgical resection was achieved in 30 patients and 32 patients had residual tumor. Twenty-five patients had recurrence or progression of the residual tumor and were treated with radiotherapy. Presenting complaints suggestive of endocrinopathy were infrequent. The most common presenting symptoms were headache, nausea and vomiting, followed by growth failure. Pre-operatively, growth hormone deficiency was the most commonly encountered pituitary hormonal deficiency; however post-operatively, most children had diabetes insipidus. Multiple pituitary hormonal deficiencies were more frequently observed in children treated with extensive radical surgery than in those treated with conservative surgery and radiotherapy. The endocrine morbidity associated with craniopharyngioma and its different management modalities remains high; however, it is manageable with appropriate hormonal replacement therapy.

Original languageEnglish (US)
Pages (from-to)869-874
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume14
Issue number7
DOIs
StatePublished - Jan 1 2001

Keywords

  • Brain tumors
  • Caniopharyngioma
  • Growth hormone deficiency
  • Hypopituitarism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Bin-Abbas, B., Mawlawi, H., Sakati, N., Khafaja, Y., Chaudhary, M. A., & Al-Ashwal, A. (2001). Endocrine sequelae of childhood craniopharyngioma. Journal of Pediatric Endocrinology and Metabolism, 14(7), 869-874. https://doi.org/10.1515/JPEM.2001.14.7.869