Endocrine sequelae of childhood craniopharyngioma

B. Bin-Abbas, H. Mawlawi, N. Sakati, Y. Khafaja, M. A. Chaudhary, A. Al-Ashwal

Research output: Contribution to journalArticle

Abstract

The endocrine sequelae of 62 children with craniopharyngioma were studied retrospectively. These patients were followed for a median duration of 3 years (range 1 to 10 years). Eighteen patients had a long-term follow-up for more than 5 years (range 5 to 10 years). Complete surgical resection was achieved in 30 patients and 32 patients had residual tumor. Twenty-five patients had recurrence or progression of the residual tumor and were treated with radiotherapy. Presenting complaints suggestive of endocrinopathy were infrequent. The most common presenting symptoms were headache, nausea and vomiting, followed by growth failure. Pre-operatively, growth hormone deficiency was the most commonly encountered pituitary hormonal deficiency; however post-operatively, most children had diabetes insipidus. Multiple pituitary hormonal deficiencies were more frequently observed in children treated with extensive radical surgery than in those treated with conservative surgery and radiotherapy. The endocrine morbidity associated with craniopharyngioma and its different management modalities remains high; however, it is manageable with appropriate hormonal replacement therapy.

Original languageEnglish (US)
Pages (from-to)869-874
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume14
Issue number7
StatePublished - 2001
Externally publishedYes

Fingerprint

Craniopharyngioma
Residual Neoplasm
Radiotherapy
Diabetes Insipidus
Nausea
Growth Hormone
Vomiting
Headache
Morbidity
Recurrence
Growth

Keywords

  • Brain tumors
  • Caniopharyngioma
  • Growth hormone deficiency
  • Hypopituitarism

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Bin-Abbas, B., Mawlawi, H., Sakati, N., Khafaja, Y., Chaudhary, M. A., & Al-Ashwal, A. (2001). Endocrine sequelae of childhood craniopharyngioma. Journal of Pediatric Endocrinology and Metabolism, 14(7), 869-874.

Endocrine sequelae of childhood craniopharyngioma. / Bin-Abbas, B.; Mawlawi, H.; Sakati, N.; Khafaja, Y.; Chaudhary, M. A.; Al-Ashwal, A.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 14, No. 7, 2001, p. 869-874.

Research output: Contribution to journalArticle

Bin-Abbas, B, Mawlawi, H, Sakati, N, Khafaja, Y, Chaudhary, MA & Al-Ashwal, A 2001, 'Endocrine sequelae of childhood craniopharyngioma', Journal of Pediatric Endocrinology and Metabolism, vol. 14, no. 7, pp. 869-874.
Bin-Abbas B, Mawlawi H, Sakati N, Khafaja Y, Chaudhary MA, Al-Ashwal A. Endocrine sequelae of childhood craniopharyngioma. Journal of Pediatric Endocrinology and Metabolism. 2001;14(7):869-874.
Bin-Abbas, B. ; Mawlawi, H. ; Sakati, N. ; Khafaja, Y. ; Chaudhary, M. A. ; Al-Ashwal, A. / Endocrine sequelae of childhood craniopharyngioma. In: Journal of Pediatric Endocrinology and Metabolism. 2001 ; Vol. 14, No. 7. pp. 869-874.
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