TY - JOUR
T1 - Endocrine impact of pure estradiol replacement in postmenopausal women
T2 - Alterations in anterior pituitary hormone release and circulating sex steroid hormone concentrations
AU - Veldhuis, Johannes D.
AU - Samojlik, Eugene
AU - Evans, William S.
AU - Rogol, Alan D.
AU - Ridgeway, Chester E.
AU - Crowley, William F.
AU - Kolp, Lisa
AU - Checinska, Eva
AU - Kirschner, Marvin A.
AU - Thorner, Michael O.
AU - Stumpf, Paul
PY - 1986/8
Y1 - 1986/8
N2 - Thirteen healthy postmenopausal volunteers were studied under basal conditions and at intervals (days 1, 5, 10, and 30) after intravaginal placement of a polysiloxane ring impregnated with 400 mg of estradiol. Mean serum estradiol concentrations rose 26-fold with a twofold increase in serum estrone concentrations. Serum Δ4-androstenedione, dehydroepiandrosterone sulfate, and total testosterone did not change, but absolute and percent free testosterone concentrations declined significantly by day 5. Concurrently, serum concentrations of immunoactive follicle-stimulating hormone declined progressively, while serum luteinizing hormone and free α-subunit concentrations exhibited a biphasic pattern of suppression. Serum levels of prolactin increased monophasically and those of growth hormone, somatomedin C, and thyroid-stimulating hormone did not change.
AB - Thirteen healthy postmenopausal volunteers were studied under basal conditions and at intervals (days 1, 5, 10, and 30) after intravaginal placement of a polysiloxane ring impregnated with 400 mg of estradiol. Mean serum estradiol concentrations rose 26-fold with a twofold increase in serum estrone concentrations. Serum Δ4-androstenedione, dehydroepiandrosterone sulfate, and total testosterone did not change, but absolute and percent free testosterone concentrations declined significantly by day 5. Concurrently, serum concentrations of immunoactive follicle-stimulating hormone declined progressively, while serum luteinizing hormone and free α-subunit concentrations exhibited a biphasic pattern of suppression. Serum levels of prolactin increased monophasically and those of growth hormone, somatomedin C, and thyroid-stimulating hormone did not change.
KW - Estradiol
KW - gonadotropins
KW - menopause
KW - pituitary
KW - sex steroids
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U2 - 10.1016/0002-9378(86)90821-5
DO - 10.1016/0002-9378(86)90821-5
M3 - Article
C2 - 3740150
AN - SCOPUS:0022502823
SN - 0002-9378
VL - 155
SP - 334
EP - 339
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 2
ER -