Endocrine features of an adrenal-like tumor of the ovary

E. Y. Adashi, Z. Rosenwaks, P. A. Lee, G. S. Jones, C. J. Migeon

Research output: Contribution to journalArticle

Abstract

Detailed in vivo endocrine studies of a virilizing adrenal-like tumor of the ovary are reported. A nonspecific steroidogenic baseline profile was observed in the face of clearcut histological adrenal-like features. Dynamic testing disclosed incomplete dexamethasone-related steroidogenic suppression suggestive of partial tumoral autonomy. At the same time, the observation of sizable dexamethasone-related steroidogenic decrements, unaccounted for by normal adrenal contribution, may be interpreted to suggest a direct, pharmacological, inhibitory effect of dexamethasone on tumoral and/or ovarian stromal steroidogenesis. These observations confirm the limited role of baseline steroid profiling and dynamic testing in the preoperative localization of androgen-secreting tumors. Reversible dysfunction of hypothalamic gonadotropic feedback mechanisms was suggested by combined single dose LRH-clomiphene testing. Complete resolution followed tumor removal.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume48
Issue number2
StatePublished - 1979

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Dexamethasone
Tumors
Ovary
Testing
Neoplasms
Clomiphene
Androgens
Steroids
Observation
Pharmacology
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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Adashi, E. Y., Rosenwaks, Z., Lee, P. A., Jones, G. S., & Migeon, C. J. (1979). Endocrine features of an adrenal-like tumor of the ovary. Journal of Clinical Endocrinology and Metabolism, 48(2), 241-245.

Endocrine features of an adrenal-like tumor of the ovary. / Adashi, E. Y.; Rosenwaks, Z.; Lee, P. A.; Jones, G. S.; Migeon, C. J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 48, No. 2, 1979, p. 241-245.

Research output: Contribution to journalArticle

Adashi, EY, Rosenwaks, Z, Lee, PA, Jones, GS & Migeon, CJ 1979, 'Endocrine features of an adrenal-like tumor of the ovary', Journal of Clinical Endocrinology and Metabolism, vol. 48, no. 2, pp. 241-245.
Adashi EY, Rosenwaks Z, Lee PA, Jones GS, Migeon CJ. Endocrine features of an adrenal-like tumor of the ovary. Journal of Clinical Endocrinology and Metabolism. 1979;48(2):241-245.
Adashi, E. Y. ; Rosenwaks, Z. ; Lee, P. A. ; Jones, G. S. ; Migeon, C. J. / Endocrine features of an adrenal-like tumor of the ovary. In: Journal of Clinical Endocrinology and Metabolism. 1979 ; Vol. 48, No. 2. pp. 241-245.
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