Endocrine effects of marijuana

Research output: Contribution to journalArticle

Abstract

In the 35 years since the active compound of marijuana, Δ9-tetrahydrocannabinol, was isolated, the psychological and physiological impact of marijuana use has been actively investigated. Animal models have demonstrated that cannabinoid administration acutely alters multiple hormonal systems, including the suppression of the gonadal steroids, growth hormone, prolactin, and thyroid hormone and the activation of the hypothalamic-pituitary-adrenal axis. These effects are mediated by binding to the endogenous cannabinoid receptor in or near the hypothalamus. Despite these findings in animals, the effects in humans have been inconsistent, and discrepancies are likely due in part to the development of tolerance. The long-term consequences of marijuana use in humans on endocrine systems remain unclear.

Original languageEnglish (US)
JournalJournal of Clinical Pharmacology
Volume42
Issue number11 SUPPL.
StatePublished - Nov 1 2002

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Cannabis
Cannabinoid Receptors
Endocrine System
Dronabinol
Cannabinoids
Gonadal Steroid Hormones
Thyroid Hormones
Prolactin
Growth Hormone
Hypothalamus
Animal Models
Psychology

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Endocrine effects of marijuana. / Brown, Todd T; Dobs, Adrian S.

In: Journal of Clinical Pharmacology, Vol. 42, No. 11 SUPPL., 01.11.2002.

Research output: Contribution to journalArticle

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