Abstract
Objective. To investigate the incidence of endocrinopathies in holoprosencephaly (HPE) and correlate the severity of the endocrinopathies with the neuroanatomic abnormalities. Study design. We reviewed the histories and medical records of 117 children with HPE for endocrinopathies and related treatments. Neuro-imaging studies were graded for severity of HPE, hypothalamus non-separation, and pituitary abnormalities. Results. Diabetes insipidus (DI) occurred in 70% of patients with classic HPE. The severity of the DI correlated with the grade of HPE and hypothalamic non-separation (p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 935-941 |
| Number of pages | 7 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 18 |
| Issue number | 10 |
| State | Published - Oct 2005 |
Keywords
- Diabetes insipidus
- Endocrinopathy
- Holoprosencephaly
- Malformation
- Syntelencephy
ASJC Scopus subject areas
- Endocrinology
- Pediatrics, Perinatology, and Child Health