Endocrine disorders associated with holoprosencephaly

Jin S. Hahn, Sara M. Hahn, Heather Kammann, A. James Barkovich, Nancy J. Clegg, Mauricio R. Delgado, Eric Levey

Research output: Contribution to journalArticle

Abstract

Objective. To investigate the incidence of endocrinopathies in holoprosencephaly (HPE) and correlate the severity of the endocrinopathies with the neuroanatomic abnormalities. Study design. We reviewed the histories and medical records of 117 children with HPE for endocrinopathies and related treatments. Neuro-imaging studies were graded for severity of HPE, hypothalamus non-separation, and pituitary abnormalities. Results. Diabetes insipidus (DI) occurred in 70% of patients with classic HPE. The severity of the DI correlated with the grade of HPE and hypothalamic non-separation (p

Original languageEnglish (US)
Pages (from-to)935-941
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume18
Issue number10
StatePublished - Oct 2005

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Holoprosencephaly
Diabetes Insipidus
Hypothalamus
Medical Records
Incidence

Keywords

  • Diabetes insipidus
  • Endocrinopathy
  • Holoprosencephaly
  • Malformation
  • Syntelencephy

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hahn, J. S., Hahn, S. M., Kammann, H., Barkovich, A. J., Clegg, N. J., Delgado, M. R., & Levey, E. (2005). Endocrine disorders associated with holoprosencephaly. Journal of Pediatric Endocrinology and Metabolism, 18(10), 935-941.

Endocrine disorders associated with holoprosencephaly. / Hahn, Jin S.; Hahn, Sara M.; Kammann, Heather; Barkovich, A. James; Clegg, Nancy J.; Delgado, Mauricio R.; Levey, Eric.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 18, No. 10, 10.2005, p. 935-941.

Research output: Contribution to journalArticle

Hahn, JS, Hahn, SM, Kammann, H, Barkovich, AJ, Clegg, NJ, Delgado, MR & Levey, E 2005, 'Endocrine disorders associated with holoprosencephaly', Journal of Pediatric Endocrinology and Metabolism, vol. 18, no. 10, pp. 935-941.
Hahn JS, Hahn SM, Kammann H, Barkovich AJ, Clegg NJ, Delgado MR et al. Endocrine disorders associated with holoprosencephaly. Journal of Pediatric Endocrinology and Metabolism. 2005 Oct;18(10):935-941.
Hahn, Jin S. ; Hahn, Sara M. ; Kammann, Heather ; Barkovich, A. James ; Clegg, Nancy J. ; Delgado, Mauricio R. ; Levey, Eric. / Endocrine disorders associated with holoprosencephaly. In: Journal of Pediatric Endocrinology and Metabolism. 2005 ; Vol. 18, No. 10. pp. 935-941.
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