Endocrine complications after solid-organ transplant in cystic fibrosis

Aniket Sidhaye, Bracha Goldswieg, Beth Kaminski, Scott M. Blackman, Andrea Kelly

Research output: Contribution to journalArticle

Abstract

In individuals with cystic fibrosis (CF), severe pulmonary or liver disease is frequently addressed with lung or liver transplant, respectively. Specific endocrine co-morbidities including diabetes mellitus, osteoporosis, and adrenal insufficiency accompany solid organ transplant and may be particularly problematic in individuals with CF, who are already at increased risk of diabetes and compromised bone health. Diabetes and osteoporosis screening and initiation of appropriate preventive measures are recommended prior to transplant. We review the existing data to provide practitioners with guidance regarding management of these endocrine conditions post-transplant. Further studies are needed to establish appropriate screening strategies and treatment regimens for endocrine complications of solid organ transplant in patients with CF.

Original languageEnglish (US)
Pages (from-to)S111-S119
JournalJournal of Cystic Fibrosis
Volume18
DOIs
StatePublished - Oct 2019

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Keywords

  • Adrenal insufficiency
  • Cystic fibrosis
  • Diabetes mellitus
  • Lung transplant
  • Osteoporosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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