Ending preventable maternal and newborn deaths due to infection

Meghana Desale, Jadsada Thinkhamrop, Pisake Lumbiganon, Shamim Qazi, Jean Anderson

Research output: Contribution to journalArticle

Abstract

Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

Fingerprint

Maternal Death
Newborn Infant
Infection
Stillbirth
Spontaneous Abortion
Rupture
Vaccines
Mothers
Morbidity
Pregnancy
Membranes
Mortality
Research

Keywords

  • HIV
  • Malaria
  • Maternal sepsis
  • Neonatal sepsis
  • Respiratory syncytial virus
  • Syphilis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ending preventable maternal and newborn deaths due to infection. / Desale, Meghana; Thinkhamrop, Jadsada; Lumbiganon, Pisake; Qazi, Shamim; Anderson, Jean.

In: Best Practice and Research: Clinical Obstetrics and Gynaecology, 2016.

Research output: Contribution to journalArticle

@article{25c44b39ee854cd8914eaf10142e1ae8,
title = "Ending preventable maternal and newborn deaths due to infection",
abstract = "Over 300,000 maternal deaths occur each year, 11{\%} of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.",
keywords = "HIV, Malaria, Maternal sepsis, Neonatal sepsis, Respiratory syncytial virus, Syphilis",
author = "Meghana Desale and Jadsada Thinkhamrop and Pisake Lumbiganon and Shamim Qazi and Jean Anderson",
year = "2016",
doi = "10.1016/j.bpobgyn.2016.05.008",
language = "English (US)",
journal = "Best Practice and Research in Clinical Obstetrics and Gynaecology",
issn = "1521-6934",
publisher = "Bailliere Tindall Ltd",

}

TY - JOUR

T1 - Ending preventable maternal and newborn deaths due to infection

AU - Desale, Meghana

AU - Thinkhamrop, Jadsada

AU - Lumbiganon, Pisake

AU - Qazi, Shamim

AU - Anderson, Jean

PY - 2016

Y1 - 2016

N2 - Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

AB - Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

KW - HIV

KW - Malaria

KW - Maternal sepsis

KW - Neonatal sepsis

KW - Respiratory syncytial virus

KW - Syphilis

UR - http://www.scopus.com/inward/record.url?scp=84978795092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978795092&partnerID=8YFLogxK

U2 - 10.1016/j.bpobgyn.2016.05.008

DO - 10.1016/j.bpobgyn.2016.05.008

M3 - Article

C2 - 27450868

AN - SCOPUS:84978795092

JO - Best Practice and Research in Clinical Obstetrics and Gynaecology

JF - Best Practice and Research in Clinical Obstetrics and Gynaecology

SN - 1521-6934

ER -