Endemic cholera in rural Bangladesh, 1966-1980

Roger I. Glass, Stanley Becker, M. Imdadul Huq, Barbara J. Stoll, M. U. Khan, Michael H. Merson, John V. Lee, Robert E Black

Research output: Contribution to journalArticle

Abstract

Since 1963, the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR.B), formerly the Cholera Research Laboratory, has maintained a field station in Matlab to treat patients from a surveillance population of 240,000 who have cholera and other diarrheal diseases. Since 1966, the authors have analyzed hospital records of 7141 surveillance-area patients culture-positive for V. cholerae 01 to relate the seasonally, age and sex distribution, and geographic trends with hypotheses concerning transmission, immunity, and risk groups. From this review, they have found that: 1) children 2-9 years old and adult women are most commonly hospitalized for cholera; 2) V. cholerae 01 emerges simultaneously throughout the area of surveillance, with the early cases being of different phage types; 3) three patients were hospitalized twice for cholera compared with 29 expected on the basis of life-table analysis (p <0.01), suggesting that Immunity to severe disease conferred by previous Illness may be stable and long-lasting; 4) no constant relationship was found between the times of onset or peaks of the yearly cholera epidemic and the times of onset or peaks of the monsoon rains or river water levels; and 5) an outbreak of multiply antibiotic-resistant V. cholerae 01 infection documented in 1979 raises questions about the dissemination of resistance plasmids, antibiotic-use patterns, and the need for other drugs in addition to tetracycline. While little progress has been made in understanding the mode of transmission of V. cholerae 01, and in Identifying practices for prevention, fluid therapy in this area has decreased the case fatality rate significantly and provides guidance for similar programs elsewhere.

Original languageEnglish (US)
Pages (from-to)959-970
Number of pages12
JournalAmerican Journal of Epidemiology
Volume116
Issue number6
StatePublished - Dec 1982
Externally publishedYes

Fingerprint

Bangladesh
Cholera
Immunity
Population Surveillance
Sex Distribution
Life Tables
Rain
Hospital Records
Fluid Therapy
Age Distribution
Microbial Drug Resistance
Tetracycline
Research
Rivers
Bacteriophages
Disease Outbreaks
Plasmids
Anti-Bacterial Agents
Mortality
Water

Keywords

  • Cholera
  • Diarrhea
  • Vibrlo cholerae

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Glass, R. I., Becker, S., Huq, M. I., Stoll, B. J., Khan, M. U., Merson, M. H., ... Black, R. E. (1982). Endemic cholera in rural Bangladesh, 1966-1980. American Journal of Epidemiology, 116(6), 959-970.

Endemic cholera in rural Bangladesh, 1966-1980. / Glass, Roger I.; Becker, Stanley; Huq, M. Imdadul; Stoll, Barbara J.; Khan, M. U.; Merson, Michael H.; Lee, John V.; Black, Robert E.

In: American Journal of Epidemiology, Vol. 116, No. 6, 12.1982, p. 959-970.

Research output: Contribution to journalArticle

Glass, RI, Becker, S, Huq, MI, Stoll, BJ, Khan, MU, Merson, MH, Lee, JV & Black, RE 1982, 'Endemic cholera in rural Bangladesh, 1966-1980', American Journal of Epidemiology, vol. 116, no. 6, pp. 959-970.
Glass RI, Becker S, Huq MI, Stoll BJ, Khan MU, Merson MH et al. Endemic cholera in rural Bangladesh, 1966-1980. American Journal of Epidemiology. 1982 Dec;116(6):959-970.
Glass, Roger I. ; Becker, Stanley ; Huq, M. Imdadul ; Stoll, Barbara J. ; Khan, M. U. ; Merson, Michael H. ; Lee, John V. ; Black, Robert E. / Endemic cholera in rural Bangladesh, 1966-1980. In: American Journal of Epidemiology. 1982 ; Vol. 116, No. 6. pp. 959-970.
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