Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Mateus H. Gouveia; Isaac Otim; Martin D. Ogwang; Wang Mingyi; Bin Zhu; Nathan Cole; Wen Luo; Hicks Belynda; Kristine Jones; Kathrin Oehl-Huber; Leona W. Ayers; Stefania Pittaluga; Ismail D. Legason; Hadijah Nabalende; Patrick Kerchan; Tobias Kinyera; Esther Kawira; Glen Brubaker; Arthur Levin; Lutz Guertler; Jung Kim; Douglas Stewart; Melissa Adde; Ian Magrath; Andrew W. Bergen; Steven J. Reynolds; Meredith Yeager; Kishor Bhatia; Adebowale A. Adeyemo; Ludmila Prokunina-Olsson; Michael Dean; Daniel Shriner; Charles N. Rotimi; Stephen Chanock; Reiner Siebert; Sam M. Mbulaiteye

doi:10.1038/s41375-020-01052-w

Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Mateus H. Gouveia, Isaac Otim, Martin D. Ogwang, Wang Mingyi, Bin Zhu, Nathan Cole, Wen Luo, Hicks Belynda, Kristine Jones, Kathrin Oehl-Huber, Leona W. Ayers, Stefania Pittaluga, Ismail D. Legason, Hadijah Nabalende, Patrick Kerchan, Tobias Kinyera, Esther Kawira, Glen Brubaker, Arthur Levin, Lutz GuertlerJung Kim, Douglas Stewart, Melissa Adde, Ian Magrath, Andrew W. Bergen, Steven J. Reynolds, Meredith Yeager, Kishor Bhatia, Adebowale A. Adeyemo, Ludmila Prokunina-Olsson, Michael Dean, Daniel Shriner, Charles N. Rotimi, Stephen Chanock, Reiner Siebert, Sam M. Mbulaiteye

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Journal	Leukemia
DOIs	https://doi.org/10.1038/s41375-020-01052-w
State	Accepted/In press - 2020
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1038/s41375-020-01052-w

Cite this

Gouveia, M. H., Otim, I., Ogwang, M. D., Mingyi, W., Zhu, B., Cole, N., Luo, W., Belynda, H., Jones, K., Oehl-Huber, K., Ayers, L. W., Pittaluga, S., Legason, I. D., Nabalende, H., Kerchan, P., Kinyera, T., Kawira, E., Brubaker, G., Levin, A., ... Mbulaiteye, S. M. (Accepted/In press). Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility. Leukemia. https://doi.org/10.1038/s41375-020-01052-w

Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda : in-depth genome-wide analysis suggests clues about genetic susceptibility. / Gouveia, Mateus H.; Otim, Isaac; Ogwang, Martin D.; Mingyi, Wang; Zhu, Bin; Cole, Nathan; Luo, Wen; Belynda, Hicks; Jones, Kristine; Oehl-Huber, Kathrin; Ayers, Leona W.; Pittaluga, Stefania; Legason, Ismail D.; Nabalende, Hadijah; Kerchan, Patrick; Kinyera, Tobias; Kawira, Esther; Brubaker, Glen; Levin, Arthur; Guertler, Lutz; Kim, Jung; Stewart, Douglas; Adde, Melissa; Magrath, Ian; Bergen, Andrew W.; Reynolds, Steven J.; Yeager, Meredith; Bhatia, Kishor; Adeyemo, Adebowale A.; Prokunina-Olsson, Ludmila; Dean, Michael; Shriner, Daniel; Rotimi, Charles N.; Chanock, Stephen; Siebert, Reiner; Mbulaiteye, Sam M.

In: Leukemia, 2020.

Research output: Contribution to journal › Article › peer-review

Gouveia, MH, Otim, I, Ogwang, MD, Mingyi, W, Zhu, B, Cole, N, Luo, W, Belynda, H, Jones, K, Oehl-Huber, K, Ayers, LW, Pittaluga, S, Legason, ID, Nabalende, H, Kerchan, P, Kinyera, T, Kawira, E, Brubaker, G, Levin, A, Guertler, L, Kim, J, Stewart, D, Adde, M, Magrath, I, Bergen, AW, Reynolds, SJ, Yeager, M, Bhatia, K, Adeyemo, AA, Prokunina-Olsson, L, Dean, M, Shriner, D, Rotimi, CN, Chanock, S, Siebert, R & Mbulaiteye, SM 2020, 'Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility', Leukemia. https://doi.org/10.1038/s41375-020-01052-w

Gouveia, Mateus H. ; Otim, Isaac ; Ogwang, Martin D. ; Mingyi, Wang ; Zhu, Bin ; Cole, Nathan ; Luo, Wen ; Belynda, Hicks ; Jones, Kristine ; Oehl-Huber, Kathrin ; Ayers, Leona W. ; Pittaluga, Stefania ; Legason, Ismail D. ; Nabalende, Hadijah ; Kerchan, Patrick ; Kinyera, Tobias ; Kawira, Esther ; Brubaker, Glen ; Levin, Arthur ; Guertler, Lutz ; Kim, Jung ; Stewart, Douglas ; Adde, Melissa ; Magrath, Ian ; Bergen, Andrew W. ; Reynolds, Steven J. ; Yeager, Meredith ; Bhatia, Kishor ; Adeyemo, Adebowale A. ; Prokunina-Olsson, Ludmila ; Dean, Michael ; Shriner, Daniel ; Rotimi, Charles N. ; Chanock, Stephen ; Siebert, Reiner ; Mbulaiteye, Sam M. / Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda : in-depth genome-wide analysis suggests clues about genetic susceptibility. In: Leukemia. 2020.

@article{6900c02e860c46d0bd2072df43a74645,

title = "Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility",

author = "Gouveia, {Mateus H.} and Isaac Otim and Ogwang, {Martin D.} and Wang Mingyi and Bin Zhu and Nathan Cole and Wen Luo and Hicks Belynda and Kristine Jones and Kathrin Oehl-Huber and Ayers, {Leona W.} and Stefania Pittaluga and Legason, {Ismail D.} and Hadijah Nabalende and Patrick Kerchan and Tobias Kinyera and Esther Kawira and Glen Brubaker and Arthur Levin and Lutz Guertler and Jung Kim and Douglas Stewart and Melissa Adde and Ian Magrath and Bergen, {Andrew W.} and Reynolds, {Steven J.} and Meredith Yeager and Kishor Bhatia and Adeyemo, {Adebowale A.} and Ludmila Prokunina-Olsson and Michael Dean and Daniel Shriner and Rotimi, {Charles N.} and Stephen Chanock and Reiner Siebert and Mbulaiteye, {Sam M.}",

note = "Funding Information: Acknowledgements We thank the study subjects for their participation. We thank Dr. Joseph Fraumeni Jr, former Director of the Division of Cancer Epidemiology and Genetics (DCEG) at National Cancer Institute (NCI), for his support and scientific guidance while conducting this study. We thank Ms. Janet Lawler-Heavner at Westat Inc. (Rockville, MD, USA) and Mr. Erisa Sunday at the African Field Epidemiology Network (Kampala, Uganda) for managing the study. We thank Ms. Laurie Buck, Dr. Carol Giffen, and Mr. Greg Rydzak at Information Management Services Inc. (Calverton, MD, USA) for preparing data analysis files. We thank the members of the tumor genetic group at the Institute of Human Genetics for expert technical assistance and fruitful discussions and Josef H{\"o}gel for support with CADD score evaluation. The study was funded by the Intramural Funding Information: Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) (Contracts HHSN261201100063C and HHSN261201100007I), the Intramural Research Program, National Institute of Allergy and Infectious Diseases (SJR) and Center for Research on Genomics & Global Health, National Human Genome Research Institute, National Institutes of Health (NIH), Department of Health and Human Services, and, in part, by intramural funds of the Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany. The infrastructural support of the KinderKrebsInitiative Buchholz/Holm-Seppensen to the group at the Institute of Human Genetics in Ulm is gratefully acknowledged. The authors acknowledge the research contributions of the Cancer Genomics Research Laboratory for their expertise, execution, and support of this research in the areas of project planning, wet laboratory processing of specimens, and bioinformatics analysis of generated data. from the NCI, NIH, under NCI Contract No. 75N910D00024. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The content of this manuscript is the sole responsibility of the authors.",

year = "2020",

doi = "10.1038/s41375-020-01052-w",

language = "English (US)",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda

T2 - in-depth genome-wide analysis suggests clues about genetic susceptibility

AU - Gouveia, Mateus H.

AU - Otim, Isaac

AU - Ogwang, Martin D.

AU - Mingyi, Wang

AU - Zhu, Bin

AU - Cole, Nathan

AU - Luo, Wen

AU - Belynda, Hicks

AU - Jones, Kristine

AU - Oehl-Huber, Kathrin

AU - Ayers, Leona W.

AU - Pittaluga, Stefania

AU - Legason, Ismail D.

AU - Nabalende, Hadijah

AU - Kerchan, Patrick

AU - Kinyera, Tobias

AU - Kawira, Esther

AU - Brubaker, Glen

AU - Levin, Arthur

AU - Guertler, Lutz

AU - Kim, Jung

AU - Stewart, Douglas

AU - Adde, Melissa

AU - Magrath, Ian

AU - Bergen, Andrew W.

AU - Reynolds, Steven J.

AU - Yeager, Meredith

AU - Bhatia, Kishor

AU - Adeyemo, Adebowale A.

AU - Prokunina-Olsson, Ludmila

AU - Dean, Michael

AU - Shriner, Daniel

AU - Rotimi, Charles N.

AU - Chanock, Stephen

AU - Siebert, Reiner

AU - Mbulaiteye, Sam M.

N1 - Funding Information: Acknowledgements We thank the study subjects for their participation. We thank Dr. Joseph Fraumeni Jr, former Director of the Division of Cancer Epidemiology and Genetics (DCEG) at National Cancer Institute (NCI), for his support and scientific guidance while conducting this study. We thank Ms. Janet Lawler-Heavner at Westat Inc. (Rockville, MD, USA) and Mr. Erisa Sunday at the African Field Epidemiology Network (Kampala, Uganda) for managing the study. We thank Ms. Laurie Buck, Dr. Carol Giffen, and Mr. Greg Rydzak at Information Management Services Inc. (Calverton, MD, USA) for preparing data analysis files. We thank the members of the tumor genetic group at the Institute of Human Genetics for expert technical assistance and fruitful discussions and Josef Högel for support with CADD score evaluation. The study was funded by the Intramural Funding Information: Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) (Contracts HHSN261201100063C and HHSN261201100007I), the Intramural Research Program, National Institute of Allergy and Infectious Diseases (SJR) and Center for Research on Genomics & Global Health, National Human Genome Research Institute, National Institutes of Health (NIH), Department of Health and Human Services, and, in part, by intramural funds of the Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany. The infrastructural support of the KinderKrebsInitiative Buchholz/Holm-Seppensen to the group at the Institute of Human Genetics in Ulm is gratefully acknowledged. The authors acknowledge the research contributions of the Cancer Genomics Research Laboratory for their expertise, execution, and support of this research in the areas of project planning, wet laboratory processing of specimens, and bioinformatics analysis of generated data. from the NCI, NIH, under NCI Contract No. 75N910D00024. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The content of this manuscript is the sole responsibility of the authors.

PY - 2020

Y1 - 2020

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UR - http://www.scopus.com/inward/citedby.url?scp=85092479594&partnerID=8YFLogxK

U2 - 10.1038/s41375-020-01052-w

DO - 10.1038/s41375-020-01052-w

M3 - Article

AN - SCOPUS:85092479594

JO - Leukemia

JF - Leukemia

SN - 0887-6924

ER -