Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative

Takashi Tsukamoto, Tomonori Yoshiyama, Tomoya Kitazume

Research output: Contribution to journalArticle

Abstract

(R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-β,β-difluoromalic acid 1.

Original languageEnglish (US)
Pages (from-to)759-762
Number of pages4
JournalTetrahedron: Asymmetry
Volume2
Issue number8
DOIs
StatePublished - 1991

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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