Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative

Takashi Tsukamoto, Tomonori Yoshiyama, Tomoya Kitazume

Research output: Contribution to journalArticle


(R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-β,β-difluoromalic acid 1.

Original languageEnglish (US)
Pages (from-to)759-762
Number of pages4
JournalTetrahedron: Asymmetry
Issue number8
StatePublished - 1991


ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this