Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative

Takashi Tsukamoto; Tomonori Yoshiyama; Tomoya Kitazume

doi:10.1016/S0957-4166(00)80453-X

Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative

Takashi Tsukamoto, Tomonori Yoshiyama, Tomoya Kitazume

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

(R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-β,β-difluoromalic acid 1.

Original language	English (US)
Pages (from-to)	759-762
Number of pages	4
Journal	Tetrahedron: Asymmetry
Volume	2
Issue number	8
DOIs	https://doi.org/10.1016/S0957-4166(00)80453-X
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative",

abstract = "(R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-β,β-difluoromalic acid 1.",

author = "Takashi Tsukamoto and Tomonori Yoshiyama and Tomoya Kitazume",

year = "1991",

doi = "10.1016/S0957-4166(00)80453-X",

language = "English (US)",

volume = "2",

pages = "759--762",

journal = "Tetrahedron: Asymmetry",

issn = "0957-4166",

publisher = "Elsevier Limited",

number = "8",

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T1 - Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative

AU - Tsukamoto, Takashi

AU - Yoshiyama, Tomonori

AU - Kitazume, Tomoya

PY - 1991

Y1 - 1991

N2 - (R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-β,β-difluoromalic acid 1.

AB - (R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-β,β-difluoromalic acid 1.

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U2 - 10.1016/S0957-4166(00)80453-X

DO - 10.1016/S0957-4166(00)80453-X

M3 - Article

AN - SCOPUS:0025773134

SN - 0957-4166

VL - 2

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JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

IS - 8

ER -

Enantioselective synthesis of β,β-difluoromalic acid via enzymic resolution of furyl substituted derivative

Abstract

ASJC Scopus subject areas

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