Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example

Xiang Guo Li, Anne Roivainen, Jörgen Bergman, Arttu Heinonen, Frank Bengel, Thomas Thum, Juhani Knuuti

Research output: Contribution to journalArticle

Abstract

A bicyclononyne-based prosthetic group has been developed for 18F-labeling of anti-microRNA-21, an oligonucleotide, in a near-stoichiometric manner.

Original languageEnglish (US)
Pages (from-to)9821-9824
Number of pages4
JournalChemical Communications
Volume51
Issue number48
DOIs
StatePublished - Jun 18 2015
Externally publishedYes

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Positron emission tomography
Oligonucleotides
Prosthetics
MicroRNAs
Labeling
bicyclo(6.1.0)nonyne

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications : [18F]-anti-microRNA-21 as an example. / Li, Xiang Guo; Roivainen, Anne; Bergman, Jörgen; Heinonen, Arttu; Bengel, Frank; Thum, Thomas; Knuuti, Juhani.

In: Chemical Communications, Vol. 51, No. 48, 18.06.2015, p. 9821-9824.

Research output: Contribution to journalArticle

Li, Xiang Guo ; Roivainen, Anne ; Bergman, Jörgen ; Heinonen, Arttu ; Bengel, Frank ; Thum, Thomas ; Knuuti, Juhani. / Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications : [18F]-anti-microRNA-21 as an example. In: Chemical Communications. 2015 ; Vol. 51, No. 48. pp. 9821-9824.
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