Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Praful R. Nair; Denis Wirtz

doi:10.1083/JCB.201902035

Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Praful R. Nair, Denis Wirtz

Whiting School of Engineering

Research output: Contribution to journal › Short survey › peer-review

Abstract

Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

Original language	English (US)
Pages (from-to)	1092-1093
Number of pages	2
Journal	Journal of Cell Biology
Volume	218
Issue number	4
DOIs	https://doi.org/10.1083/JCB.201902035
State	Published - Apr 1 2019

ASJC Scopus subject areas

Cell Biology

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10.1083/JCB.201902035

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title = "Enabling migration by moderation: YAP/TAZ are essential for persistent migration",

abstract = "Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.",

author = "Nair, {Praful R.} and Denis Wirtz",

note = "Funding Information: This work was supported by National In stitutes of Health grants U54CA210173 and U01AG060903. Publisher Copyright: {\textcopyright} 2019 Nair and Wirtz.",

year = "2019",

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doi = "10.1083/JCB.201902035",

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AU - Nair, Praful R.

AU - Wirtz, Denis

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N2 - Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

AB - Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

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Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Abstract

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