TY - JOUR
T1 - Employment-based reinforcement of adherence to an FDA approved extended release formulation of naltrexone in opioid-dependent adults
T2 - A randomized controlled trial
AU - DeFulio, Anthony
AU - Everly, Jeffrey J.
AU - Leoutsakos, Jeannie Marie S.
AU - Umbricht, Annie
AU - Fingerhood, Michael
AU - Bigelow, George E.
AU - Silverman, Kenneth
N1 - Funding Information:
This research was supported by grants R01DA019497 and T32DA07209 from the National Institute on Drug Abuse (NIDA) , and Alkermes, Inc. supplied the medication used in this study at no cost. Neither NIDA or Alkermes, Inc. had any further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse or the National Institutes of Health.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Background: Naltrexone provides excellent opioid blockade, but its clinical utility is limited because opioid-dependent patients typically refuse it. An injectable suspension of naltrexone for extended release (XR-NTX) was recently approved by the FDA for treatment of opioid dependence. XR-NTX treatment may require concurrent behavioral intervention to maximize adherence and effectiveness, thus we sought to evaluate employment-based reinforcement as a method of improving adherence to XR-NTX in opiate dependent adults. Methods: Opioid-dependent adults (n = 38) were detoxified and inducted onto oral naltrexone, then randomly assigned to contingency or prescription conditions. Participants received up to six doses of XR-NTX at four-week intervals. All participants could earn vouchers for attendance and performance at a therapeutic workplace. Contingency participants were required to accept XR-NTX injections to access the workplace and earn vouchers. Prescription participants could earn vouchers independent of their acceptance of XR-NTX injections. Results: Contingency participants accepted significantly more naltrexone injections than prescription participants (87% versus 52%, p= .002), and were more likely to accept all injections (74% versus 26%, p= .004). Participants in the two conditions provided similar percentages of samples negative for opiates (72% versus 65%) and for cocaine (58% versus 54%). Opiate positivity was significantly more likely when samples were also cocaine positive, independent of naltrexone blockade (p= .002). Conclusions: Long-term adherence to XR-NTX in unemployed opiate dependent adults is low under usual care conditions. Employment-based reinforcement can maintain adherence to XR-NTX. Ongoing cocaine use appears to interfere with the clinical effectiveness of XR-NTX on opiate use.
AB - Background: Naltrexone provides excellent opioid blockade, but its clinical utility is limited because opioid-dependent patients typically refuse it. An injectable suspension of naltrexone for extended release (XR-NTX) was recently approved by the FDA for treatment of opioid dependence. XR-NTX treatment may require concurrent behavioral intervention to maximize adherence and effectiveness, thus we sought to evaluate employment-based reinforcement as a method of improving adherence to XR-NTX in opiate dependent adults. Methods: Opioid-dependent adults (n = 38) were detoxified and inducted onto oral naltrexone, then randomly assigned to contingency or prescription conditions. Participants received up to six doses of XR-NTX at four-week intervals. All participants could earn vouchers for attendance and performance at a therapeutic workplace. Contingency participants were required to accept XR-NTX injections to access the workplace and earn vouchers. Prescription participants could earn vouchers independent of their acceptance of XR-NTX injections. Results: Contingency participants accepted significantly more naltrexone injections than prescription participants (87% versus 52%, p= .002), and were more likely to accept all injections (74% versus 26%, p= .004). Participants in the two conditions provided similar percentages of samples negative for opiates (72% versus 65%) and for cocaine (58% versus 54%). Opiate positivity was significantly more likely when samples were also cocaine positive, independent of naltrexone blockade (p= .002). Conclusions: Long-term adherence to XR-NTX in unemployed opiate dependent adults is low under usual care conditions. Employment-based reinforcement can maintain adherence to XR-NTX. Ongoing cocaine use appears to interfere with the clinical effectiveness of XR-NTX on opiate use.
KW - Contingency management
KW - Extended-release naltrexone
KW - Heroin
KW - Incentives
KW - Opioid pharmacotherapy
KW - Therapeutic workplace
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U2 - 10.1016/j.drugalcdep.2011.06.023
DO - 10.1016/j.drugalcdep.2011.06.023
M3 - Article
C2 - 21782353
AN - SCOPUS:84155164801
SN - 0376-8716
VL - 120
SP - 48
EP - 54
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
IS - 1-3
ER -