@article{5886aaf896c6412db15cf62266ba7ea7,
title = "Empiric antifungal therapy and outcomes in extremely low birth weight infants with invasive candidiasis",
abstract = "Objective: To assess the impact of empiric antifungal therapy for invasive candidiasis on subsequent outcomes in premature infants. Study design: This was a cohort study of infants with a birth weight ≤1000 g receiving care at Neonatal Research Network sites. All infants had at least one positive culture for Candida. Empiric antifungal therapy was defined as receipt of a systemic antifungal on the day of or the day before the first positive culture for Candida was drawn. We created Cox proportional hazards and logistic regression models stratified on propensity score quartiles to determine the effect of empiric antifungal therapy on survival, time to clearance of infection, retinopathy of prematurity, bronchopulmonary dysplasia, end-organ damage, and neurodevelopmental impairment (NDI). Results: A total of 136 infants developed invasive candidiasis. The incidence of death or NDI was lower in infants who received empiric antifungal therapy (19 of 38; 50%) compared with those who had not (55 of 86; 64%; OR, 0.27; 95% CI, 0.08-0.86). There was no significant difference between the groups for any single outcome or other combined outcomes. Conclusion: Empiric antifungal therapy was associated with increased survival without NDI. A prospective randomized trial of this strategy is warranted.",
author = "Greenberg, {Rachel G.} and Benjamin, {Daniel K.} and Gantz, {Marie G.} and Cotten, {C. Michael} and Stoll, {Barbara J.} and Walsh, {Michele C.} and S{\'a}nchez, {Pablo J.} and Seetha Shankaran and Abhik Das and Higgins, {Rosemary D.} and Miller, {Nancy A.} and Auten, {Kathy J.} and Walsh, {Thomas J.} and Laptook, {Abbot R.} and Carlo, {Waldemar A.} and Kennedy, {Kathleen A.} and Finer, {Neil N.} and Shahnaz Duara and Kurt Schibler and Ehrenkranz, {Richard A.} and {Van Meurs}, {Krisa P.} and Frantz, {Ivan D.} and Phelps, {Dale L.} and Poindexter, {Brenda B.} and Bell, {Edward F.} and O'Shea, {T. Michael} and Watterberg, {Kristi L.} and Goldberg, {Ronald N.} and Smith, {P. Brian}",
note = "Funding Information: The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development provided grant support for the Neonatal Research Network's Candidiasis Study. Funding Information: D.B. receives support from the United States Government for his work in pediatric and neonatal clinical pharmacology ( 1R01HD057956-02, 1R01FD003519-01, 1U10-HD45962-06, 1K24HD058735-01 , and government contract HHSN267200700051C ), the nonprofit Thrasher Research Foundation for his work in neonatal candidiasis, and Astellas Pharma US, CV Therapeutics, Inc, Johnson and Johnson, Pangen Biosystems, Inc, and Pzifer for neonatal and pediatric drug development. B.S. received support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grants 1K23HD060040-01 and 1R18AE000028-01 ). Data collected at participating sites of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Network were transmitted to RTI International, the data coordinating center for the network, which stored, managed, and analyzed the data for this study. Study sponsors were not involved in the study design; collection, analysis, and interpretation of the data; writing of the report; or the decision to submit the manuscript for publication. The other authors declare no conflicts of interest. ",
year = "2012",
month = aug,
doi = "10.1016/j.jpeds.2012.01.053",
language = "English (US)",
volume = "161",
pages = "264--269.e2",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",
}