Emphysematous cholecystitis in a patient with gastrointestinal stromal tumor treated with sunitinib

Gilberto De Lima Lopes, Caio Max Rocha Lima

Research output: Contribution to journalArticle

Abstract

A 50-year-old man had a metastatic gastrointestinal stromal tumor that was refractory to imatinib. He was prescribed a 6-week course of treatment with oral sunitinib 50 mg/day. During the fourth week of his first cycle of treatment with the drug, the patient developed acute-onset, right upper quadrant pain associated with nausea, vomiting, and fever; laboratory tests revealed leukocytosis and mild hyperbilirubinemia. He was diagnosed with acute emphysematous cholecystitis, which was treated with broad-spectrum antibiotics and percutaneous cholecystostomy. His symptoms resolved, and he successfully completed his course of therapy with sunitinib. Using the Naranjo adverse drug reaction probability scale, a score of 5 was derived, which indicates that the likelihood was probable that this adverse event was caused by sunitinib.

Original languageEnglish (US)
Pages (from-to)775-777
Number of pages3
JournalPharmacotherapy
Volume27
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Emphysematous Cholecystitis
Gastrointestinal Stromal Tumors
Cholecystostomy
Acute Cholecystitis
Hyperbilirubinemia
Leukocytosis
Drug-Related Side Effects and Adverse Reactions
Nausea
Vomiting
Fever
Therapeutics
Anti-Bacterial Agents
Pain
Pharmaceutical Preparations
sunitinib

Keywords

  • Angiogenesis
  • Emphysematous cholecystitis
  • Gastrointestinal stromal tumor
  • Sunitinib
  • Vascular endothelial growth factor
  • VEGF

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Emphysematous cholecystitis in a patient with gastrointestinal stromal tumor treated with sunitinib. / De Lima Lopes, Gilberto; Rocha Lima, Caio Max.

In: Pharmacotherapy, Vol. 27, No. 5, 05.2007, p. 775-777.

Research output: Contribution to journalArticle

De Lima Lopes, Gilberto ; Rocha Lima, Caio Max. / Emphysematous cholecystitis in a patient with gastrointestinal stromal tumor treated with sunitinib. In: Pharmacotherapy. 2007 ; Vol. 27, No. 5. pp. 775-777.
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