TY - JOUR
T1 - Emphysematous cholecystitis in a patient with gastrointestinal stromal tumor treated with sunitinib
AU - De Lima Lopes, Gilberto
AU - Rocha Lima, Caio Max
PY - 2007/5/1
Y1 - 2007/5/1
N2 - A 50-year-old man had a metastatic gastrointestinal stromal tumor that was refractory to imatinib. He was prescribed a 6-week course of treatment with oral sunitinib 50 mg/day. During the fourth week of his first cycle of treatment with the drug, the patient developed acute-onset, right upper quadrant pain associated with nausea, vomiting, and fever; laboratory tests revealed leukocytosis and mild hyperbilirubinemia. He was diagnosed with acute emphysematous cholecystitis, which was treated with broad-spectrum antibiotics and percutaneous cholecystostomy. His symptoms resolved, and he successfully completed his course of therapy with sunitinib. Using the Naranjo adverse drug reaction probability scale, a score of 5 was derived, which indicates that the likelihood was probable that this adverse event was caused by sunitinib.
AB - A 50-year-old man had a metastatic gastrointestinal stromal tumor that was refractory to imatinib. He was prescribed a 6-week course of treatment with oral sunitinib 50 mg/day. During the fourth week of his first cycle of treatment with the drug, the patient developed acute-onset, right upper quadrant pain associated with nausea, vomiting, and fever; laboratory tests revealed leukocytosis and mild hyperbilirubinemia. He was diagnosed with acute emphysematous cholecystitis, which was treated with broad-spectrum antibiotics and percutaneous cholecystostomy. His symptoms resolved, and he successfully completed his course of therapy with sunitinib. Using the Naranjo adverse drug reaction probability scale, a score of 5 was derived, which indicates that the likelihood was probable that this adverse event was caused by sunitinib.
KW - Angiogenesis
KW - Emphysematous cholecystitis
KW - Gastrointestinal stromal tumor
KW - Sunitinib
KW - VEGF
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=34247892273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247892273&partnerID=8YFLogxK
U2 - 10.1592/phco.27.5.775
DO - 10.1592/phco.27.5.775
M3 - Article
C2 - 17461715
AN - SCOPUS:34247892273
SN - 0277-0008
VL - 27
SP - 775
EP - 777
JO - Pharmacotherapy
JF - Pharmacotherapy
IS - 5
ER -