Emphysema quantification on cardiac CT scans using hidden markov measure field model: The MESA lung study

Jie Yang, Elsa D. Angelini, Pallavi P. Balte, Eric A. Hoffman, Colin O. Wu, Bharath A. Venkatesh, R. Graham Barr, Andrew F. Laine

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Cardiac computed tomography (CT) scans include approximately 2/3 of the lung and can be obtained with low radiation exposure. Large cohorts of population-based research studies reported high correlations of emphysema quantification between full-lung (FL) and cardiac CT scans,using thresholding-based measurements. This work extends a hidden Markov measure field (HMMF) model-based segmentation method for automated emphysema quantification on cardiac CT scans. We show that the HMMF-based method,when compared with several types of thresholding,provides more reproducible emphysema segmentation on repeated cardiac scans,and more consistent measurements between longitudinal cardiac and FL scans from a diverse pool of scanner types and thousands of subjects with ten thousands of scans.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
EditorsGozde Unal, Sebastian Ourselin, Leo Joskowicz, Mert R. Sabuncu, William Wells
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783319467221
StatePublished - 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9901 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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