TY - JOUR
T1 - Emotional memory in early steroid abnormalities
T2 - An fMRI study of adolescents with congenital adrenal hyperplasia
AU - Mazzone, Luigi
AU - Mueller, Sven C.
AU - Maheu, Francoise
AU - Vanryzin, Carol
AU - Merke, Deborah P.
AU - Ernst, Monique
N1 - Funding Information:
We thank the staff of the NIH MR Center for making this study possible. FSM was supported by a postdoctoral fellowship from the Fonds de la recherche en sante du Quebec (FRSQ). This work was supported in part by the intramural program of NICHD and NIMH, NIH.
PY - 2011/5
Y1 - 2011/5
N2 - Hormonal imbalances during development may have long-lasting effects. Using functional magnetic resonance imaging (fMRI), we compared 14 youths with Congenital Adrenal Hyperplasia (CAH), a genetic disorder of hormonal dysfunction, with 22 healthy controls on memory encoding of emotional faces. Patients remembered fewer faces than controls, particularly fearful faces. FMRI data to successfully encoded fearful faces revealed that males with CAH showed significant activations in amygdala, hippocampus, and anterior cingulate relative to unaffected males, while females with CAH demonstrated deactivations relative to unaffected females in these regions. Findings indicate that steroid abnormalities during development can have important effects on neural correlates of emotional memory.
AB - Hormonal imbalances during development may have long-lasting effects. Using functional magnetic resonance imaging (fMRI), we compared 14 youths with Congenital Adrenal Hyperplasia (CAH), a genetic disorder of hormonal dysfunction, with 22 healthy controls on memory encoding of emotional faces. Patients remembered fewer faces than controls, particularly fearful faces. FMRI data to successfully encoded fearful faces revealed that males with CAH showed significant activations in amygdala, hippocampus, and anterior cingulate relative to unaffected males, while females with CAH demonstrated deactivations relative to unaffected females in these regions. Findings indicate that steroid abnormalities during development can have important effects on neural correlates of emotional memory.
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U2 - 10.1080/87565641.2010.549866
DO - 10.1080/87565641.2010.549866
M3 - Article
C2 - 21516544
AN - SCOPUS:79956201829
SN - 8756-5641
VL - 36
SP - 473
EP - 492
JO - Developmental Neuropsychology
JF - Developmental Neuropsychology
IS - 4
ER -