TY - JOUR
T1 - Emerging treatments for metastatic castration-resistant prostate cancer
T2 - Immunotherapy, PARP inhibitors, and PSMA-targeted approaches
AU - Marshall, Catherine Handy
AU - Antonarakis, Emmanuel S.
N1 - Funding Information:
Disclosures: CHM has received research funding to her institution from the Conquer Cancer Foundation (Bristol Myers Squibb) and travel support from Dava Oncology. She also serves as a paid consultant to McGraw-Hill publishing company. ESA is a paid consultant/advisor to Janssen, Astellas, Sanofi, Dendreon, Pfizer, Amgen, AstraZeneca, Bristol-Myers Squibb, Clovis, and Merck. He has received research funding to his institution from Janssen, Johnson & Johnson, Sanofi, Dendreon, Genentech, Novartis, Tokai, Bristol-Myers-Squibb, AstraZeneca, Clovis, and Merck; and he is the co-inventor of a biomarker technology that has been licensed to Qiagen. Funding: This work was partially supported by National Institute of Health Cancer Center Support Grant P30CA006973.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020
Y1 - 2020
N2 - Recently there has been an explosion of new agents being investigated for the treatment of prostate cancer. These modalities represent new therapies aimed at old targets, and new therapies addressing new targets. This review will highlight three novel and emerging areas of treatment that have the potential to significantly impact the management of metastatic castration-resistant prostate cancer (mCRPC) in the near future: immunotherapy, poly ADP-ribose polymerase (PARP) inhibitors, and prostate-specific membrane antigen (PSMA)-targeted modalities. Immunotherapy, particularly immune checkpoint blockers, PARP inhibitors, and PSMA-targeted therapies are all increasingly being studied for the treatment of mCRPC although none are currently FDA-approved specifically for prostate cancer. Together these three classes of treatments may drastically change the future landscape of mCRPC. This review will cover what is currently known about the utility of these agents for the treatment of mCRPC, the areas of active research, and how these agents may be useful for patients in the future. It will also emphasize the notion of biomarker selection to help inform which patients are more likely to respond to these therapies.
AB - Recently there has been an explosion of new agents being investigated for the treatment of prostate cancer. These modalities represent new therapies aimed at old targets, and new therapies addressing new targets. This review will highlight three novel and emerging areas of treatment that have the potential to significantly impact the management of metastatic castration-resistant prostate cancer (mCRPC) in the near future: immunotherapy, poly ADP-ribose polymerase (PARP) inhibitors, and prostate-specific membrane antigen (PSMA)-targeted modalities. Immunotherapy, particularly immune checkpoint blockers, PARP inhibitors, and PSMA-targeted therapies are all increasingly being studied for the treatment of mCRPC although none are currently FDA-approved specifically for prostate cancer. Together these three classes of treatments may drastically change the future landscape of mCRPC. This review will cover what is currently known about the utility of these agents for the treatment of mCRPC, the areas of active research, and how these agents may be useful for patients in the future. It will also emphasize the notion of biomarker selection to help inform which patients are more likely to respond to these therapies.
KW - Immune checkpoint blockers
KW - Immunotherapy
KW - Metastatic castration-resistant prostate cancer
KW - PARP inhibitors
KW - PSMA
KW - Prostate cancer
KW - Targeted therapy
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U2 - 10.1016/j.ctarc.2020.100164
DO - 10.1016/j.ctarc.2020.100164
M3 - Article
C2 - 31978677
AN - SCOPUS:85078552123
SN - 2213-0896
VL - 23
JO - Cancer Treatment and Research Communications
JF - Cancer Treatment and Research Communications
M1 - 100164
ER -