Emerging Therapies for Spastic Movement Disorders

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4 Scopus citations


Spasticity develops as a result of central nervous system (CNS) injury; however, secondary changes within the muscles and connective tissue also contribute to muscle stiffness. The hyaluronan hypothesis postulates that the accumulation of hyaluronan promotes the development of muscle stiffness. Intramuscular injections of the enzyme hyaluronidase, which hydrolyzes long-chained hyaluronan polymers to smaller polymers, was shown to reduce muscle stiffness and increase passive and active range of motion in patients with spasticity. These results provide preliminary evidence of the hyaluronan hypothesis and suggest an emerging therapy to reduce muscle stiffness using the enzyme hyaluronidase.

Original languageEnglish (US)
Pages (from-to)633-644
Number of pages12
JournalPhysical Medicine and Rehabilitation Clinics of North America
Issue number3
StatePublished - Aug 2018
Externally publishedYes


  • Brain injury
  • Hyaluronan hypothesis
  • Hyaluronic acid
  • Hyaluronidase
  • Muscle stiffness
  • Peripheral mechanism
  • Spasticity
  • Stroke

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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