Emerging themes from the literature on circulating biomarkers of traumatic brain injury

Karolina Paziana, Frederick K. Korley

Research output: Contribution to journalReview articlepeer-review


Objective diagnosis of traumatic brain injury (TBI) and early prediction of TBI-associated outcome remains a significant clinical challenge with major public health implications. The use of circulating biomarkers to quantify TBI has promise for real-time clinical decision making and may help clinicians determine the need for advanced imaging, and guide an individualized approach to the management of TBI. In this review of the literature, we provide an overview of candidate TBI biomarkers and discuss several themes emerging from the literature on TBI biomarkers. We suggest that the future utility of TBI biomarkers lies in the creation of composite panels of biomarkers tailored to the pursuit of specific clinic questions.

Original languageEnglish (US)
Pages (from-to)281-291
Number of pages11
JournalFuture Neurology
Issue number3
StatePublished - May 1 2015


  • MRNA
  • S100B
  • biomarker
  • brain-derived neurotrophic factor
  • cleaved Tau
  • glial fibrillary acidic protein
  • myelin-based protein
  • neuron specific enolase
  • spectrin breakdown product
  • traumatic brain injury
  • ubiquitin C-terminal hydrolase-L1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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