Emerging technologies in organ preservation, tissue engineering and regenerative medicine: a blessing or curse for transplantation?

Franka Messner, Yinan Guo, Joanna W. Etra, Gerald Brandacher

Research output: Contribution to journalReview articlepeer-review

Abstract

Since the beginning of transplant medicine in the 1950s, advances in surgical technique and immunosuppressive therapy have created the success story of modern organ transplantation. However, today more than ever, we are facing a huge discrepancy between organ supply and demand, limiting the potential for transplantation to save and improve the lives of millions. To address the current limitations and shortcomings, a variety of emerging new technologies focusing on either maximizing the availability of organs or on generating new organs and organ sources hold great potential to eventully overcoming these hurdles. These advances are mainly in the field of regenerative medicine and tissue engineering. This review gives an overview of this emerging field and its multiple sub-disciplines and highlights recent advances and existing limitations for widespread clinical application and potential impact on the future of transplantation.

Original languageEnglish (US)
Pages (from-to)673-685
Number of pages13
JournalTransplant International
Volume32
Issue number7
DOIs
StatePublished - Jul 2019

Keywords

  • cryopreservation
  • machine perfusion
  • regenerative medicine
  • tissue and organ biofabrification
  • tissue engineering
  • transplantation

ASJC Scopus subject areas

  • Transplantation

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