Emerging strategies to effectively target autophagy in cancer

V. W. Rebecca, R. K. Amaravadi

Research output: Contribution to journalReview articlepeer-review

Abstract

Autophagy serves a dichotomous role in cancer and recent advances have helped delineate the appropriate settings where inhibiting or promoting autophagy may confer therapeutic efficacy in patients. Our evolving understanding of the molecular machinery responsible for the tightly controlled regulation of this homeostatic mechanism has begun to bear fruit in the way of autophagy-oriented clinical trials and promising lead compounds to modulate autophagy for therapeutic benefit. In this manuscript we review the recent preclinical and clinical therapeutic strategies that involve autophagy modulation in cancer.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalOncogene
Volume35
Issue number1
DOIs
StatePublished - Jan 7 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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