Emerging role for the cytoskeleton as an organizer and regulator of translation

Seyun Kim; Pierre A. Coulombe

doi:10.1038/nrm2818

Emerging role for the cytoskeleton as an organizer and regulator of translation

Seyun Kim, Pierre A. Coulombe

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the cytoskeleton participates in the spatial organization and regulation of translation, at both the global and local level, in a manner that is crucial for cellular growth, proliferation and function.

Original language	English (US)
Pages (from-to)	75-81
Number of pages	7
Journal	Nature Reviews Molecular Cell Biology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/nrm2818
State	Published - Jan 2010
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm2818

Cite this

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abstract = "The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the cytoskeleton participates in the spatial organization and regulation of translation, at both the global and local level, in a manner that is crucial for cellular growth, proliferation and function.",

author = "Seyun Kim and Coulombe, {Pierre A.}",

note = "Funding Information: We apologize to all scientists whose work has not been appro‑ priately discussed owing to space limitations. The authors thank C. Parent for advice. This effort was supported by grant AR44232 from the National Institutes of Health.",

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AU - Coulombe, Pierre A.

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Y1 - 2010/1

N2 - The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the cytoskeleton participates in the spatial organization and regulation of translation, at both the global and local level, in a manner that is crucial for cellular growth, proliferation and function.

AB - The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the cytoskeleton participates in the spatial organization and regulation of translation, at both the global and local level, in a manner that is crucial for cellular growth, proliferation and function.

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Emerging role for the cytoskeleton as an organizer and regulator of translation

Abstract

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