Emerging Role for PDE4 in Neuropsychiatric Disorders: Translating Advances from Genetic Studies Into Relevant Therapeutic Strategies

Sandra P. Zoubovsky; Akira Sawa; Nicholas J. Brandon

doi:10.1002/9781118836507.ch08

Emerging Role for PDE4 in Neuropsychiatric Disorders: Translating Advances from Genetic Studies Into Relevant Therapeutic Strategies

Sandra P. Zoubovsky, Akira Sawa, Nicholas J. Brandon

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Recent data from human genetics, various flavors of animal models, and molecular pharmacology studies implicate disturbances of cyclic nucleotide signaling in neuropsychiatric disorders. This chapter highlights the role of the cAMP phosphodiesterase PDE4 in the pathophysiology of three major neuropsychiatric disorders: schizophrenia, depression, and Huntington's disease.

Original language	English (US)
Title of host publication	Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System
Subtitle of host publication	From Biology to Drug Discovery
Publisher	Wiley-Blackwell
Pages	211-222
Number of pages	12
ISBN (Electronic)	9781118836507
ISBN (Print)	9780470566688
DOIs	https://doi.org/10.1002/9781118836507.ch08
State	Published - Apr 28 2014

Keywords

Depression
Huntington's disease
PDE4
Schizophrenia

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology
General Neuroscience
General Medicine

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10.1002/9781118836507.ch08

Cite this

Emerging Role for PDE4 in Neuropsychiatric Disorders: Translating Advances from Genetic Studies Into Relevant Therapeutic Strategies. / Zoubovsky, Sandra P.; Sawa, Akira; Brandon, Nicholas J.
Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. Wiley-Blackwell, 2014. p. 211-222.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Emerging Role for PDE4 in Neuropsychiatric Disorders: Translating Advances from Genetic Studies Into Relevant Therapeutic Strategies

Abstract

Keywords

ASJC Scopus subject areas

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