Emerging Role for PDE4 in Neuropsychiatric Disorders: Translating Advances from Genetic Studies Into Relevant Therapeutic Strategies

Sandra P. Zoubovsky, Akira Sawa, Nicholas J. Brandon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent data from human genetics, various flavors of animal models, and molecular pharmacology studies implicate disturbances of cyclic nucleotide signaling in neuropsychiatric disorders. This chapter highlights the role of the cAMP phosphodiesterase PDE4 in the pathophysiology of three major neuropsychiatric disorders: schizophrenia, depression, and Huntington's disease.

Original languageEnglish (US)
Title of host publicationCyclic-Nucleotide Phosphodiesterases in the Central Nervous System
Subtitle of host publicationFrom Biology to Drug Discovery
PublisherWiley-Blackwell
Pages211-222
Number of pages12
ISBN (Electronic)9781118836507
ISBN (Print)9780470566688
DOIs
StatePublished - Apr 28 2014

Keywords

  • Depression
  • Huntington's disease
  • PDE4
  • Schizophrenia

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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