Emerging monoclonal antibody therapies for malignant gliomas

David E. Gerber, John Laterra

Research output: Contribution to journalReview article

Abstract

An improved understanding of the molecular characteristics of gliomas has led to the recognition of potential antigen targets and monoclonal antibody (mAb) therapies for these challenging tumors. The design of glioma mAbs - including species, construct, immunoglobulin isotype and conjugate - affects their delivery, efficacy and toxicities. mAbs that are under study for glioma therapy include some mAbs that are currently approved for use in the treatment of other cancers, as well as novel molecules. Although the greatest experience so far is with locally administered, radiolabeled mAbs, systemic unconjugated mAbs are being studied increasingly for glioma treatment. Previous experience with mAbs in other malignancies may provide guidance for their use in the treatment of CNS malignancies.

Original languageEnglish (US)
Pages (from-to)477-494
Number of pages18
JournalExpert Opinion on Investigational Drugs
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2007

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Keywords

  • Antibody-dependent cellular cytotoxicity
  • Blood-brain barrier
  • Brain tumor
  • Glioma
  • Monoclonal antibody
  • Radioisotope
  • Receptor tyrosine kinase
  • Targeted therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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