Abstract
Neural guidance cues are essential for a growing axon to correctly course through the body and innervate target tissues. Interestingly, the vascular network follows a parallel trajectory along nerves, suggesting that guidance cues important for neural patterning may also be required for proper vascular patterning. However, while an axon arises from one cell, a blood vessel is composed of many endothelial cells. Recent evidence suggests that neural repulsive cues are usurped by multi-cellular blood vessels to ensure vascular stabilization cues. Additional clues into the signaling mechanisms that promote vascular stabilization are emerging from cerebral cavernous malformations, a disease characterized by headache, epilepsy, and stroke. Thus, neurobiology and neurology are providing insights into the concepts of vascular stability.
Original language | English (US) |
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Pages (from-to) | 57-60 |
Number of pages | 4 |
Journal | Journal of Thrombosis and Haemostasis |
Volume | 7 |
Issue number | SUPPL. 1 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- CCM
- Hemostasis
- Neurovascular guidance
- Robo4
- Vascular stability
ASJC Scopus subject areas
- Hematology