Emerging mechanisms of vascular stabilization

N. R. London, M. C.P. Smith, Dean Y. Li

Research output: Contribution to journalReview article

Abstract

Neural guidance cues are essential for a growing axon to correctly course through the body and innervate target tissues. Interestingly, the vascular network follows a parallel trajectory along nerves, suggesting that guidance cues important for neural patterning may also be required for proper vascular patterning. However, while an axon arises from one cell, a blood vessel is composed of many endothelial cells. Recent evidence suggests that neural repulsive cues are usurped by multi-cellular blood vessels to ensure vascular stabilization cues. Additional clues into the signaling mechanisms that promote vascular stabilization are emerging from cerebral cavernous malformations, a disease characterized by headache, epilepsy, and stroke. Thus, neurobiology and neurology are providing insights into the concepts of vascular stability.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalJournal of Thrombosis and Haemostasis
Volume7
Issue numberSUPPL. 1
DOIs
StatePublished - Aug 4 2009
Externally publishedYes

Keywords

  • CCM
  • Hemostasis
  • Neurovascular guidance
  • Robo4
  • Vascular stability

ASJC Scopus subject areas

  • Hematology

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