Emerging links between hypermutation of antibody genes and DNA polymerases

Patricia J. Gearhart, Richard D. Wood

Research output: Contribution to journalArticle

Abstract

Substantial antibody variability is created when nucleotide substitutions are introduced into immunoglobulin variable genes by a controlled process of hypermutation. Evidence points to a mechanism involving DNA repair events at sites of targeted breaks. In vertebrate cells, there are many recently identified DNA polymerases that inaccurately copy templates. Some of these are candidates for enzymes that introduce base changes during hypermutation. Recent research has focused on possible roles for DNA polymerases ζ (POLZ), η (POLH), ι (POLI), and μ (POLM) in the process.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalNature Reviews Immunology
Volume1
Issue number3
StatePublished - Dec 2001
Externally publishedYes

Fingerprint

DNA-Directed DNA Polymerase
Immunoglobulin Genes
Antibodies
DNA Repair
Genes
Vertebrates
Nucleotides
Enzymes
Research

ASJC Scopus subject areas

  • Immunology

Cite this

Emerging links between hypermutation of antibody genes and DNA polymerases. / Gearhart, Patricia J.; Wood, Richard D.

In: Nature Reviews Immunology, Vol. 1, No. 3, 12.2001, p. 187-192.

Research output: Contribution to journalArticle

Gearhart, Patricia J. ; Wood, Richard D. / Emerging links between hypermutation of antibody genes and DNA polymerases. In: Nature Reviews Immunology. 2001 ; Vol. 1, No. 3. pp. 187-192.
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