In recent years, increased molecular testing and improved immunohistochemical panels have facilitated more specific classification of salivary gland carcinomas, leading to recognition of several novel tumor types and unique histologic variants. Sclerosing microcystic adenocarcinoma, microsecretory adenocarcinoma, and secretory myoepithelial carcinoma are three such recently described entities that demonstrate low-grade cytology, production of prominent secretory material, and variable amounts of sclerotic stroma. This review provides a practical overview of these important and overlapping emerging entities in salivary gland pathology with a focus on distinctive histologic features and helpful ancillary studies that differentiate them from a wide range of familiar morphologic mimics.
- Microsecretory adenocarcinoma
- Molecular diagnostics
- Salivary gland carcinomas
- Sclerosing microcystic adenocarcinoma
- Secretory myoepithelial carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine