TY - JOUR
T1 - Emerging connections between cerebellar development, behaviour and complex brain disorders
AU - Sathyanesan, Aaron
AU - Zhou, Joy
AU - Scafidi, Joseph
AU - Heck, Detlef H.
AU - Sillitoe, Roy V.
AU - Gallo, Vittorio
N1 - Funding Information:
J.S. was supported by the US National Institute of Neurological Disorders and Stroke (NINDS) grant 5R01NS099461. R.V.S. received support from the Hamill Foundation, the Baylor College of Medicine Intellectual and Developmental Disabilities Research Center grant U54HD083092 and NINDS grants R01NS089664 and R01NS100874. D.H.H. received support from the University of Tennessee Health Science Center (UTHSC) Neuroscience Institute and the UTHSC Cornet Award. R.V.S. and D.H.H. were also supported by the US National Institute of Mental Health grant R01MH112143. V.G. was supported by the District of Columbia Intellectual and Developmental Disabilities Research Center grant U54 HD090257 and NINDS grants R01NS105138 and R37NS109478 (Javits Award).
Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders share motor deficits as a common sequela. However, evidence gathered since the late 1980s suggests that the cerebellum is involved in motor and non-motor function, including cognition and emotion. More recently, evidence indicates that major neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, attention-deficit hyperactivity disorder and Down syndrome have potential links to abnormal cerebellar development. Out of recent findings from clinical and preclinical studies, the concept of the ‘cerebellar connectome’ has emerged that can be used as a framework to link the role of cerebellar development to human behaviour, disease states and the design of better therapeutic strategies.
AB - The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders share motor deficits as a common sequela. However, evidence gathered since the late 1980s suggests that the cerebellum is involved in motor and non-motor function, including cognition and emotion. More recently, evidence indicates that major neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, attention-deficit hyperactivity disorder and Down syndrome have potential links to abnormal cerebellar development. Out of recent findings from clinical and preclinical studies, the concept of the ‘cerebellar connectome’ has emerged that can be used as a framework to link the role of cerebellar development to human behaviour, disease states and the design of better therapeutic strategies.
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U2 - 10.1038/s41583-019-0152-2
DO - 10.1038/s41583-019-0152-2
M3 - Review article
C2 - 30923348
AN - SCOPUS:85063636573
VL - 20
SP - 298
EP - 313
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
SN - 1471-003X
IS - 5
ER -