Emerging Approaches for Cardiovascular Stem Cell Imaging

Dorota A. Kedziorek, Dara L. Kraitchman

Research output: Contribution to journalReview articlepeer-review

Abstract

Stem cell therapies offer potential therapeutic alternatives for coronary artery disease, myocardial infarction, and heart failure. To a lesser extent, stem cell transplantations are used for experimental treatment of congenital heart conditions, atherosclerotic peripheral arterial disease, and other cardiovascular pathologies. The efficacy of stem cell transplants on the aforementioned diseases has been inconsistent, and the specific regenerative mechanisms by which stem cells work are not well understood. Thus, a reliable and efficient method of cell tracking and monitoring would be beneficial. The different imaging strategies and modalities for cell tracking, as well as the latest approaches to cell labeling in this field, are reviewed in the hope that this will foster a better understanding of the best methods to treat cardiovascular diseases with cellular therapeutics.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalCurrent Cardiovascular Imaging Reports
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Bioluminescence
  • Heart diseases
  • Magnetic resonance imaging
  • Optical imaging
  • Positron emission tomography
  • Single photon emission computed tomography
  • Stem cell transplantation and imaging

ASJC Scopus subject areas

  • Histology
  • Applied Microbiology and Biotechnology
  • Cell Biology

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