Emerging advances in rapid diagnostics of respiratory infections

David R. Murdoch; Lance C. Jennings; Niranjan Bhat; Trevor P. Anderson

doi:10.1016/j.idc.2010.04.006

Emerging advances in rapid diagnostics of respiratory infections

David R. Murdoch, Lance C. Jennings, Niranjan Bhat, Trevor P. Anderson

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Recent developments in rapid diagnostics for respiratory infections have mostly occurred in the areas of antigen and nucleic acid detection. Nucleic acid amplification tests have improved the ability to identify respiratory viruses in clinical specimens and have played pivotal roles in the rapid characterization of new viral pathogens. Antigen-detection assays in immunochromatographic or similar formats are most easily developed as near-patient tests, although they have been developed commercially only for a limited range of respiratory pathogens. New approaches for respiratory pathogen detection are needed, and breath analysis is an exciting area with enormous potential.

Original language	English (US)
Pages (from-to)	791-807
Number of pages	17
Journal	Infectious disease clinics of North America
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.idc.2010.04.006
State	Published - Sep 2010
Externally published	Yes

Keywords

Antigen detection
Diagnostics
Pneumonia
Polymerase chain reaction
Respiratory infection

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.idc.2010.04.006

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title = "Emerging advances in rapid diagnostics of respiratory infections",

abstract = "Recent developments in rapid diagnostics for respiratory infections have mostly occurred in the areas of antigen and nucleic acid detection. Nucleic acid amplification tests have improved the ability to identify respiratory viruses in clinical specimens and have played pivotal roles in the rapid characterization of new viral pathogens. Antigen-detection assays in immunochromatographic or similar formats are most easily developed as near-patient tests, although they have been developed commercially only for a limited range of respiratory pathogens. New approaches for respiratory pathogen detection are needed, and breath analysis is an exciting area with enormous potential.",

keywords = "Antigen detection, Diagnostics, Pneumonia, Polymerase chain reaction, Respiratory infection",

author = "Murdoch, {David R.} and Jennings, {Lance C.} and Niranjan Bhat and Anderson, {Trevor P.}",

note = "Funding Information: D.R.M. and N.B. performed part of this work under the Pneumonia Etiology Research for Child Health (PERCH) program at the Johns Hopkins Bloomberg School of Public Health funded by a grant from The Bill & Melinda Gates Foundation. N.B. is supported by grant 1KL2RR025006-01 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov/ . Information on Reengineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp . ",

year = "2010",

month = sep,

doi = "10.1016/j.idc.2010.04.006",

language = "English (US)",

volume = "24",

pages = "791--807",

journal = "Infectious disease clinics of North America",

issn = "0891-5520",

publisher = "W.B. Saunders Ltd",

number = "3",

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T1 - Emerging advances in rapid diagnostics of respiratory infections

AU - Murdoch, David R.

AU - Jennings, Lance C.

AU - Bhat, Niranjan

AU - Anderson, Trevor P.

N1 - Funding Information: D.R.M. and N.B. performed part of this work under the Pneumonia Etiology Research for Child Health (PERCH) program at the Johns Hopkins Bloomberg School of Public Health funded by a grant from The Bill & Melinda Gates Foundation. N.B. is supported by grant 1KL2RR025006-01 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov/ . Information on Reengineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp .

PY - 2010/9

Y1 - 2010/9

N2 - Recent developments in rapid diagnostics for respiratory infections have mostly occurred in the areas of antigen and nucleic acid detection. Nucleic acid amplification tests have improved the ability to identify respiratory viruses in clinical specimens and have played pivotal roles in the rapid characterization of new viral pathogens. Antigen-detection assays in immunochromatographic or similar formats are most easily developed as near-patient tests, although they have been developed commercially only for a limited range of respiratory pathogens. New approaches for respiratory pathogen detection are needed, and breath analysis is an exciting area with enormous potential.

AB - Recent developments in rapid diagnostics for respiratory infections have mostly occurred in the areas of antigen and nucleic acid detection. Nucleic acid amplification tests have improved the ability to identify respiratory viruses in clinical specimens and have played pivotal roles in the rapid characterization of new viral pathogens. Antigen-detection assays in immunochromatographic or similar formats are most easily developed as near-patient tests, although they have been developed commercially only for a limited range of respiratory pathogens. New approaches for respiratory pathogen detection are needed, and breath analysis is an exciting area with enormous potential.

KW - Antigen detection

KW - Diagnostics

KW - Pneumonia

KW - Polymerase chain reaction

KW - Respiratory infection

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Emerging advances in rapid diagnostics of respiratory infections

Abstract

Keywords

ASJC Scopus subject areas

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