Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity

Anna P. Durbin, Sandra V. Mayer, Shannan L. Rossi, Irma Y. Amaya-Larios, Jose Ramos-Castaneda, Eng Eong Ooi, M. Jane Cardosa, Jorge L. Munoz-Jordan, Robert B. Tesh, William B. Messer, Scott C. Weaver, Nikos Vasilakis

Research output: Contribution to journalArticle

Abstract

Sylvatic dengue viruses (DENV) are both evolutionarily and ecologically distinct from human DENV and are maintained in an enzootic transmission cycle. Evidence of sylvatic human infections from West Africa and Southeast Asia suggests that sylvatic DENV come into regular contact with humans. Thus, this potential of emergence into the human transmission cycle could limit the potential for eradicating this cycle with vaccines currently in late stages of development. We assessed the likelihood of sylvatic DENV-4 emergence in the face of natural immunity to current human strains and vaccination with two DENV-4 vaccine candidates. Our data indicate homotypic neutralization of sylvatic and human DENV-4 strains by human primary convalescent and vaccinee sera but limited heterotypic immunity. These results suggest that emergence of sylvatic strains into the human cycle would be limited by homotypic immunity mediated by virus neutralizing antibodies produced by natural infection or vaccination.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalVirology
Volume439
Issue number1
DOIs
StatePublished - Apr 25 2013

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Keywords

  • Antigenic relationships
  • Dengue virus (DENV)
  • Human DENV
  • Plaque reduction neutralization test (PRNT)
  • Sylvatic DENV
  • Vaccine

ASJC Scopus subject areas

  • Virology

Cite this

Durbin, A. P., Mayer, S. V., Rossi, S. L., Amaya-Larios, I. Y., Ramos-Castaneda, J., Eong Ooi, E., Jane Cardosa, M., Munoz-Jordan, J. L., Tesh, R. B., Messer, W. B., Weaver, S. C., & Vasilakis, N. (2013). Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity. Virology, 439(1), 34-41. https://doi.org/10.1016/j.virol.2013.01.018