Emergence of targeted molecular imaging in atherosclerotic cardiovascular disease

Milind Y. Desai, Paul Schoenhagen

Research output: Contribution to journalArticle

Abstract

Atherosclerosis, a systemic disease, remains one of the leading causes of morbidity and mortality in the world. Our improved understanding of the molecular mechanisms underlying atherosclerotic lesion progression and sudden transformation into unstable plaques, indicate complex interactions of lipid metabolism, inflammatory processes and genetic predisposition. Currently, novel imaging approaches to visualize the process of atherosclerosis, particularly at the molecular level, are actively being developed. Important targets include inflammatory and endothelial cells, as well as apoptosis and angiogenesis. The next decade should solidify the role of targeted molecular imaging in all aspects of cardiovascular medicine.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalExpert Review of Cardiovascular Therapy
Volume7
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • Atherosclerosis
  • Cardiovascular
  • Coronary artery disease
  • Macrophage
  • Molecular imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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