Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment

ROBERT A. KING, MARK A. RIDDLE, PHILLIP B. CHAPPELL, MAUREEN T. HARDIN, GEORGE M. ANDERSON, PAUL LOMBROSO, LARRY SCAHILL

Research output: Contribution to journalArticlepeer-review

Abstract

Self-injurious ideation or behavior appeared de novo or intensified during fluoxetine treatment of obsessive-compulsive disorder in six patients, age 10 to 17 years old, who were among 42 young patients receiving fluoxetine for obsessive-compulsive disorder at a university clinical research center. These symptoms required the hospitalization of four patients. Before receiving fluoxetine, four patients had major risk factors for self-destructive behavior including depression or prior suicidal ideation or self-injury. Three hypotheses concerning the apparent association between fluoxetine and these self-injurious phenomena are discussed: (1) coincidence; (2) disorganization of vulnerable individuals secondary to drug-induced activation; and (3) a specific serotonergic-mediated effect on the regulation of aggression.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume30
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • children
  • fluoxetine
  • obsessive-compulsive disorder
  • self-injurious behavior
  • suicide

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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