Abstract
Infection due to opportunistic moulds is an emerging problem in hematopoietic stem cell recipients. Through the 1990s, the incidence of invasive aspergillosis in allogeni0c graft recipients climbed steadily, peaking at 10% to 15%. In this decade, other opportunistic mould infections are emerging, including zygomycosis, fusariosis, and scedosporiosis. These epidemiologic changes are likely due to greater or different types of host immune suppression, medical interventions such as antifungal prophylaxis, and more successful treatment of aspergillosis, keeping immunosuppressed patients alive and at risk. The non-Aspergillus moulds generally exhibit variable susceptibility to antifungal agents, and outcomes continue to be disappointing. Thus, prevention of infection becomes a prominent concern in the care of these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 434-441 |
| Number of pages | 8 |
| Journal | Current Infectious Disease Reports |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Emergence of opportunistic mould infections in the hematopoietic stem cell transplant patient. / Upton, Arlo; Marr, Kieren.
In: Current Infectious Disease Reports, Vol. 8, No. 6, 11.2006, p. 434-441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emergence of opportunistic mould infections in the hematopoietic stem cell transplant patient
AU - Upton, Arlo
AU - Marr, Kieren
PY - 2006/11
Y1 - 2006/11
N2 - Infection due to opportunistic moulds is an emerging problem in hematopoietic stem cell recipients. Through the 1990s, the incidence of invasive aspergillosis in allogeni0c graft recipients climbed steadily, peaking at 10% to 15%. In this decade, other opportunistic mould infections are emerging, including zygomycosis, fusariosis, and scedosporiosis. These epidemiologic changes are likely due to greater or different types of host immune suppression, medical interventions such as antifungal prophylaxis, and more successful treatment of aspergillosis, keeping immunosuppressed patients alive and at risk. The non-Aspergillus moulds generally exhibit variable susceptibility to antifungal agents, and outcomes continue to be disappointing. Thus, prevention of infection becomes a prominent concern in the care of these patients.
AB - Infection due to opportunistic moulds is an emerging problem in hematopoietic stem cell recipients. Through the 1990s, the incidence of invasive aspergillosis in allogeni0c graft recipients climbed steadily, peaking at 10% to 15%. In this decade, other opportunistic mould infections are emerging, including zygomycosis, fusariosis, and scedosporiosis. These epidemiologic changes are likely due to greater or different types of host immune suppression, medical interventions such as antifungal prophylaxis, and more successful treatment of aspergillosis, keeping immunosuppressed patients alive and at risk. The non-Aspergillus moulds generally exhibit variable susceptibility to antifungal agents, and outcomes continue to be disappointing. Thus, prevention of infection becomes a prominent concern in the care of these patients.
UR - http://www.scopus.com/inward/record.url?scp=33750876577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750876577&partnerID=8YFLogxK
U2 - 10.1007/s11908-006-0017-5
DO - 10.1007/s11908-006-0017-5
M3 - Article
C2 - 17064636
AN - SCOPUS:33750876577
VL - 8
SP - 434
EP - 441
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
SN - 1523-3847
IS - 6
ER -