Abstract
Changes in the genes encoding sensory receptor proteins are an essential step in the evolution of new sensory capacities. In primates, trichromatic color vision evolved after changes in X chromosome-linked photopigment genes. To model this process, we studied knock-in mice that expressed a human long-wavelength-sensitive (L) cone photopigment in the form of an X-linked polymorphism. Behavioral tests demonstrated that heterozygous females, whose retinas contained both native mouse pigments and human L pigment, showed enhanced long-wavelength sensitivity and acquired a new capacity for chromatic discrimination. An inherent plasticity in the mammalian visual system thus permits the emergence of a new dimension of sensory experience based solely on gene-driven changes in receptor organization.
Original language | English (US) |
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Pages (from-to) | 1723-1725 |
Number of pages | 3 |
Journal | Science |
Volume | 315 |
Issue number | 5819 |
DOIs | |
State | Published - Mar 23 2007 |
ASJC Scopus subject areas
- General