Emergence of late-onset placental dysfunction: Relationship to the change in uterine artery blood flow resistance between the first and third trimesters

Elisa Llurba, Ozhan Turan, Tania Kasdaglis, Chris R. Harman, Ahmet Baschat

Research output: Contribution to journalArticle

Abstract

Objectives To test if emergence of third-trimester (T3) placental dysfunction is related to the impedance change in uterine artery blood flow resistance between the first trimester (T1) and T3. Study Design Mean T1 and T3 uterine artery (mUtA) pulsatility index (PI) was measured in 1098 singletons. Each patient's individual mUtA-PI change was calculated ([(T3 PI - T1 PI/interval in days)] × 100; ΔmUtA-PI). This parameter and T1 and T3 mUtA-PI z-scores were related to placenta-related disease (PRD) and to constitutionally small neonates (CS). Results Forty-seven (5%) women had PRD and 83 (8.7%) delivered a CS neonate. T1 and T3 mUtA-PI z-scores were higher with PRD (0.418 versus -0.097 and 1.06 versus -0.13, p <0.001 for all). Change in mUtA-PI (ΔmUtA PI) was similar for patients with PRD. However, the prevalence of PRD doubled with rising ΔmUtA-PI (11.1% versus 5.2%, p = 0.041). Conclusion T3 uterine artery Doppler performs significantly better in detecting patients at risk for late-onset PRD than T1 or the gestational age change in uterine artery Doppler resistance This suggests that a proportion of late emerging PRD is not amenable to early screening by uterine artery Doppler. Further research is essential to identify the optimal screening strategy for late-onset placental dysfunction.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalAmerican Journal of Perinatology
Volume30
Issue number6
DOIs
StatePublished - 2013
Externally publishedYes

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Placenta Diseases
Uterine Artery
Third Pregnancy Trimester
First Pregnancy Trimester
Newborn Infant
Electric Impedance
Gestational Age

Keywords

  • constitutionally small neonates
  • fetal growth restriction
  • preeclampsia
  • third trimester
  • uterine artery Doppler

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Emergence of late-onset placental dysfunction : Relationship to the change in uterine artery blood flow resistance between the first and third trimesters. / Llurba, Elisa; Turan, Ozhan; Kasdaglis, Tania; Harman, Chris R.; Baschat, Ahmet.

In: American Journal of Perinatology, Vol. 30, No. 6, 2013, p. 505-511.

Research output: Contribution to journalArticle

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abstract = "Objectives To test if emergence of third-trimester (T3) placental dysfunction is related to the impedance change in uterine artery blood flow resistance between the first trimester (T1) and T3. Study Design Mean T1 and T3 uterine artery (mUtA) pulsatility index (PI) was measured in 1098 singletons. Each patient's individual mUtA-PI change was calculated ([(T3 PI - T1 PI/interval in days)] × 100; ΔmUtA-PI). This parameter and T1 and T3 mUtA-PI z-scores were related to placenta-related disease (PRD) and to constitutionally small neonates (CS). Results Forty-seven (5{\%}) women had PRD and 83 (8.7{\%}) delivered a CS neonate. T1 and T3 mUtA-PI z-scores were higher with PRD (0.418 versus -0.097 and 1.06 versus -0.13, p <0.001 for all). Change in mUtA-PI (ΔmUtA PI) was similar for patients with PRD. However, the prevalence of PRD doubled with rising ΔmUtA-PI (11.1{\%} versus 5.2{\%}, p = 0.041). Conclusion T3 uterine artery Doppler performs significantly better in detecting patients at risk for late-onset PRD than T1 or the gestational age change in uterine artery Doppler resistance This suggests that a proportion of late emerging PRD is not amenable to early screening by uterine artery Doppler. Further research is essential to identify the optimal screening strategy for late-onset placental dysfunction.",
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