Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis

Yu Min Chuang; Sung Pin Tseng; Lee Jene Teng; Ya Chi Ho; Po Ren Hsueh

doi:10.1016/j.jinf.2005.11.002

Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis

Yu Min Chuang, Sung Pin Tseng, Lee Jene Teng, Ya Chi Ho, Po Ren Hsueh

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We present a diabetic patient with necrotizing fasciitis caused by Citrobacter freundii associated with an injury from the fish fin. Two isolates recovered six days after cefotaxime treatment had a cefotaxime minimum inhibitory concentration (MIC) of 0.12 and 256 mg/L, respectively, and a cefepime MIC of 0.03 and 0.25 mg/L, respectively. The two isolates both possessed bla_CMY-2 gene. The patient responded unsatisfactorily to cefotaxime and cefepime therapy and surgical debridement but recovered completely after ertapenem treatment for 42 days.

Original language	English (US)
Pages (from-to)	e161-e163
Journal	Journal of Infection
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/j.jinf.2005.11.002
State	Published - Sep 1 2006

Keywords

Citrobacter freundii
Necrotizing fasciitis
bla gene ertapenem

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.jinf.2005.11.002

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title = "Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis",

abstract = "We present a diabetic patient with necrotizing fasciitis caused by Citrobacter freundii associated with an injury from the fish fin. Two isolates recovered six days after cefotaxime treatment had a cefotaxime minimum inhibitory concentration (MIC) of 0.12 and 256 mg/L, respectively, and a cefepime MIC of 0.03 and 0.25 mg/L, respectively. The two isolates both possessed blaCMY-2 gene. The patient responded unsatisfactorily to cefotaxime and cefepime therapy and surgical debridement but recovered completely after ertapenem treatment for 42 days.",

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AU - Tseng, Sung Pin

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AU - Ho, Ya Chi

AU - Hsueh, Po Ren

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AB - We present a diabetic patient with necrotizing fasciitis caused by Citrobacter freundii associated with an injury from the fish fin. Two isolates recovered six days after cefotaxime treatment had a cefotaxime minimum inhibitory concentration (MIC) of 0.12 and 256 mg/L, respectively, and a cefepime MIC of 0.03 and 0.25 mg/L, respectively. The two isolates both possessed blaCMY-2 gene. The patient responded unsatisfactorily to cefotaxime and cefepime therapy and surgical debridement but recovered completely after ertapenem treatment for 42 days.

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Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis

Abstract

Keywords

ASJC Scopus subject areas

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