Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis

Yu Min Chuang, Sung Pin Tseng, Lee Jene Teng, Ya Chi Ho, Po Ren Hsueh

Research output: Contribution to journalArticle

Abstract

We present a diabetic patient with necrotizing fasciitis caused by Citrobacter freundii associated with an injury from the fish fin. Two isolates recovered six days after cefotaxime treatment had a cefotaxime minimum inhibitory concentration (MIC) of 0.12 and 256 mg/L, respectively, and a cefepime MIC of 0.03 and 0.25 mg/L, respectively. The two isolates both possessed bla CMY-2 gene. The patient responded unsatisfactorily to cefotaxime and cefepime therapy and surgical debridement but recovered completely after ertapenem treatment for 42 days.

Original languageEnglish (US)
JournalJournal of Infection
Volume53
Issue number3
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Citrobacter freundii
Necrotizing Fasciitis
Cefotaxime
Osteomyelitis
Microbial Sensitivity Tests
Debridement
Fishes
Therapeutics
Wounds and Injuries
Genes
cefepime

Keywords

  • bla gene ertapenem
  • Citrobacter freundii
  • Necrotizing fasciitis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis. / Chuang, Yu Min; Tseng, Sung Pin; Teng, Lee Jene; Ho, Ya Chi; Hsueh, Po Ren.

In: Journal of Infection, Vol. 53, No. 3, 09.2006.

Research output: Contribution to journalArticle

Chuang, Yu Min ; Tseng, Sung Pin ; Teng, Lee Jene ; Ho, Ya Chi ; Hsueh, Po Ren. / Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis. In: Journal of Infection. 2006 ; Vol. 53, No. 3.
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