Emergence of cefotaxime resistance in Citrobacter freundii causing necrotizing fasciitis and osteomyelitis

Yu Min Chuang, Sung Pin Tseng, Lee Jene Teng, Ya Chi Ho, Po Ren Hsueh

Research output: Contribution to journalArticlepeer-review

Abstract

We present a diabetic patient with necrotizing fasciitis caused by Citrobacter freundii associated with an injury from the fish fin. Two isolates recovered six days after cefotaxime treatment had a cefotaxime minimum inhibitory concentration (MIC) of 0.12 and 256 mg/L, respectively, and a cefepime MIC of 0.03 and 0.25 mg/L, respectively. The two isolates both possessed blaCMY-2 gene. The patient responded unsatisfactorily to cefotaxime and cefepime therapy and surgical debridement but recovered completely after ertapenem treatment for 42 days.

Original languageEnglish (US)
Pages (from-to)e161-e163
JournalJournal of Infection
Volume53
Issue number3
DOIs
StatePublished - Sep 1 2006

Keywords

  • Citrobacter freundii
  • Necrotizing fasciitis
  • bla gene ertapenem

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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