Embryonic stem cell-derived cardiac myocytes are not ready for human trials

Mark E. Anderson; Joshua Goldhaber; Steven R. Houser; Michel Puceat; Mark A. Sussman

doi:10.1161/CIRCRESAHA.114.304616

Embryonic stem cell-derived cardiac myocytes are not ready for human trials

Mark E. Anderson, Joshua Goldhaber, Steven R. Houser, Michel Puceat, Mark A. Sussman

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Recently, a preclinical report assessed the efficacy, safety, and feasibility of using human embryonic stem cells to regenerate infarcted myocardium in a nonhuman primate model. This commentary evaluates that study by pointing out key weaknesses, offering an alternative perspective, and summarizing major unresolved issues. Our conclusion is that significant challenges remain before human embryonic stem cells are ready for use in clinical trials.

Original language	English (US)
Pages (from-to)	335-338
Number of pages	4
Journal	Circulation research
Volume	115
Issue number	3
DOIs	https://doi.org/10.1161/CIRCRESAHA.114.304616
State	Published - Jul 18 2014
Externally published	Yes

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/CIRCRESAHA.114.304616

Cite this

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abstract = "Recently, a preclinical report assessed the efficacy, safety, and feasibility of using human embryonic stem cells to regenerate infarcted myocardium in a nonhuman primate model. This commentary evaluates that study by pointing out key weaknesses, offering an alternative perspective, and summarizing major unresolved issues. Our conclusion is that significant challenges remain before human embryonic stem cells are ready for use in clinical trials.",

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AU - Sussman, Mark A.

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AB - Recently, a preclinical report assessed the efficacy, safety, and feasibility of using human embryonic stem cells to regenerate infarcted myocardium in a nonhuman primate model. This commentary evaluates that study by pointing out key weaknesses, offering an alternative perspective, and summarizing major unresolved issues. Our conclusion is that significant challenges remain before human embryonic stem cells are ready for use in clinical trials.

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Embryonic stem cell-derived cardiac myocytes are not ready for human trials

Abstract

ASJC Scopus subject areas

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